Insulin induction of tyrosine aminotransferase in synchronized hepatoma cells
dc.contributor.author | Rettig Emanuel, Janet | en_US |
dc.contributor.author | Gelehrter, Thomas D. | en_US |
dc.date.accessioned | 2006-04-07T16:38:02Z | |
dc.date.available | 2006-04-07T16:38:02Z | |
dc.date.issued | 1975-04-21 | en_US |
dc.identifier.citation | Rettig Emanuel, Janet, Gelehrter, Thomas D. (1975/04/21)."Insulin induction of tyrosine aminotransferase in synchronized hepatoma cells." Biochemical and Biophysical Research Communications 63(4): 825-831. <http://hdl.handle.net/2027.42/22075> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DMW71T-91/2/95f18da06aeed1fae681cc0662ba1e11 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22075 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=236756&dopt=citation | en_US |
dc.description.abstract | Addition of insulin to unsynchronized rat hepatoma cells, previously incubated with dexamethasone, promotes a rapid increase in tyrosine aminotransferase activity. Mitotic cells in the presence or absence of colcemid are not inducible by either insulin or dexamethasone. Inducibility by dexamethasone is restored only after the third hour of the G1 phase, presumably related to the appearance of the putative posttranscriptional repressor ([3.]). In contrast, inducibility by insulin is restored immediately upon passage of the synchronized cells into G1. These data suggest that insulin can induce tyrosine aminotransferase in the absence of the repressor. | en_US |
dc.format.extent | 385874 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Insulin induction of tyrosine aminotransferase in synchronized hepatoma cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine, University of Michigan, Ann Arbor, MI 48104, USA | en_US |
dc.contributor.affiliationother | Department of Human Genetics, Yale University, New Haven, CT 06510, USA | en_US |
dc.identifier.pmid | 236756 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22075/1/0000495.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(75)90641-5 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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