L-kynurenine aminotransferase and L-[alpha]-aminoadipate aminotransferase. I. Evidence for identity
dc.contributor.author | Tobes, Michael C. | en_US |
dc.contributor.author | Mason, Merle | en_US |
dc.date.accessioned | 2006-04-07T16:40:22Z | |
dc.date.available | 2006-04-07T16:40:22Z | |
dc.date.issued | 1975-01-20 | en_US |
dc.identifier.citation | Tobes, Michael C., Mason, Merle (1975/01/20)."L-kynurenine aminotransferase and L-[alpha]-aminoadipate aminotransferase. I. Evidence for identity." Biochemical and Biophysical Research Communications 62(2): 390-397. <http://hdl.handle.net/2027.42/22147> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4FW08RV-4G/2/bf166e6ece557ca647febe243c5b6bbe | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22147 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1111529&dopt=citation | en_US |
dc.description.abstract | SummaryThe following observations strongly suggest that L-kynurenine aminotransferase (KAT) and L-[alpha]-aminoadipate aminotransferase (AAT) activities are associated with the same protein: 1. a similar distribution in the supernatant and mitochondrial fractions of kidney and liver of male rats, 2. a similar distribution in these fractions of kidney and liver of female rats, 3. a similar sex difference in the supernatant and mitochondrial fractions of kidney with no sex difference in liver fractions, 4. a similar pattern of inhibition with a homologous series of dicarboxylic acids with adipate being most effective, 5. competitive inhibition of KAT with d,l-[alpha]-aminoadipate ([alpha]AA), 6. substrate inhibition of KAT with [alpha]-ketoadipate ([alpha]KA), and 7. AAT activity in a highly purified preparation of KAT. A scheme for the interaction of the two activities in lysine and tryptophan metabolism is presented. | en_US |
dc.format.extent | 375856 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | L-kynurenine aminotransferase and L-[alpha]-aminoadipate aminotransferase. I. Evidence for identity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan Ann Arbor, Michigan 48104, USA | en_US |
dc.identifier.pmid | 1111529 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22147/1/0000576.pdf | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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