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Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats
dc.contributor.authorVasko, Michael R.en_US
dc.contributor.authorDomino, Laurence E.en_US
dc.contributor.authorDomino, Edward F.en_US
dc.date.accessioned2006-04-07T16:46:15Z
dc.date.available2006-04-07T16:46:15Z
dc.date.issued1974-06en_US
dc.identifier.citationVasko, Michael R., Domino, Laurence E., Domino, Edward F. (1974/06)."Differential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric rats." European Journal of Pharmacology 27(1): 145-147. <http://hdl.handle.net/2027.42/22339>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T1J-4772T4F-1BF/2/3a7206ef05974435929677261683369aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22339
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4851386&dopt=citationen_US
dc.description.abstractVarying doses of d-amphetamine were given i.p. to young (28 day old), adult (approximately 90 day old), and geriatric rats (approximately 2 years old). 30 min after injection, rats were sacrificed and ACH extracted and assayed by pyrolysis gas-liquid chromatography. Total brain acetylcholine (ACh) levels were not significantly different among the control animals in all three groups. d-Amphetamine, however, decreased total levels of ACh in young and geriatric rats without changing levels in adult animals. The changes in young rats were dose-related. These results suggest an important difference in brain cholinergic mechanisms depending upon age.en_US
dc.format.extent211310 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDifferential effects of d-amphetamine on brain acetylcholine in young, adult and geriatric ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.en_US
dc.identifier.pmid4851386en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22339/1/0000784.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-2999(74)90212-Xen_US
dc.identifier.sourceEuropean Journal of Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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