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Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats
dc.contributor.authorZiboh, Vincent A.en_US
dc.contributor.authorVanderhoek, Jack Y.en_US
dc.contributor.authorLands, William E. M.en_US
dc.date.accessioned2006-04-07T16:48:26Z
dc.date.available2006-04-07T16:48:26Z
dc.date.issued1974-02-10en_US
dc.identifier.citationZiboh, Vincent A., Vanderhoek, Jack Y., Lands, William E. M. (1974/02/10)."Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats." Prostaglandins 5(3): 233-240. <http://hdl.handle.net/2027.42/22411>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B7CRH-4GMR40P-1/2/558a2d6b23eec6c952f3943e46d4479een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22411
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4856851&dopt=citationen_US
dc.description.abstractUnsaturated fatty acids present in the lipids of essential fatty acid (EFA)-deficient rats were found to inhibit the oxygenase activity of sheep vesicular gland in an instantaneous, reversible manner. However, competitive inhibition by high levels of these acids cannot account fully for the reported loss of prostaglandin synthetic capacity of these EFA-deficient animals. A similar competitive inhibition pattern was observed with several anti-inflammatory drugs tested, whereas others also exhibited a time-dependent destructive effect on the oxygenase of the sheep vesicular gland. The relative effectiveness of these drugs in treating inflammations of the skin paralleled their effects on the vesicular gland oxygenase.en_US
dc.format.extent400842 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationotherDepartments of Dermatology and Biochemistry University of Miami School of Medicine Miami, Florida 33152, USAen_US
dc.identifier.pmid4856851en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22411/1/0000861.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0090-6980(74)90050-1en_US
dc.identifier.sourceProstaglandinsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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