Cholelithiasis in mice: Effects of different chemicals upon formation and prevention of gallstones

Abstract

Prevention of gallstones induced in mice by 1% cholesterol and 0.5% cholic acid (lithogenic diet) for 8 weeks was obtained by simultaneously feeding sulfaguanidine (1.5%) and dodecyl sodium sulfate (0.5-1.0%) along with the lithogenic diet. Citrus pectin (3%), egg lecithin (1%), n-octyl alcohol (1%), neomycin sulfate (0.2-0.5%) and -ascorbic acid (5%) added to the lithogenic diet did not prevent gallstone formation. The condition of the liver, fatty or normal, in the experiment could not be correlated with the stone formation. Lower serum and liver cholesterol levels and an elevation of lecithin concentrations in serum was noticed in mice fed the sulfaguanidine and dodecyl sodium sulfate diet.