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Bromobenzene-induced zonal necrosis in the hepatic acinus

dc.contributor.authorMiller, Deborah L.en_US
dc.contributor.authorHarasin, John M.en_US
dc.contributor.authorGumcio, Jorge J.en_US
dc.date.accessioned2006-04-07T16:57:28Z
dc.date.available2006-04-07T16:57:28Z
dc.date.issued1978-12en_US
dc.identifier.citationMiller, Deborah L., Harasin, John M., Gumcio, Jorge J. (1978/12)."Bromobenzene-induced zonal necrosis in the hepatic acinus." Experimental and Molecular Pathology 29(3): 358-370. <http://hdl.handle.net/2027.42/22475>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WFB-4C4NYTJ-PM/2/7a4c543932335c69a1231c69c71646d7en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22475
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=720545&dopt=citationen_US
dc.description.abstractThe time course and acinar distribution of bromobenzene-induced hepatic necrosis was studied in the rat. Cellular damage, lipid infiltration, and changes in glycogen deposits were investigated by light microscopy 6, 16, 24, and 48 hr after bromobenzene (BZ) administration. Concomitantly, ultrastructural changes were followed by electron microscopy in each zone of the acinus. To insure accurate orientation in acinar zones, a double embedding technique for electron microscopy was used. Acinar zones were localized by light microscopy and subsequently re-embedded for electron microscopy. Zone 3 was the site of conformational changes in smooth endoplasmic reticulum 6 hr after BZ administration. This condensed, tubular network represented the earliest morphological sign of injury observed by electron microscopy. At 48 hr, cytoplasmic vacuolar degeneration and necrosis were observed in the hepatocytes of acinar zone 3. While no necrosis was observed in the cells of zone 1, other morphological changes occurred. These included progressive lipid accumulation, as well as fluctuations in the amount of rough endoplasmic reticulum and free ribosomes. These latter observations suggested a possible link between protein manufacture and survival of the zone 1 cells. These results established that, following bromobenzene administration, necrosis was restricted to zone 3 hepatocytes.en_US
dc.format.extent1684676 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBromobenzene-induced zonal necrosis in the hepatic acinusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid720545en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22475/1/0000016.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-4800(78)90078-3en_US
dc.identifier.sourceExperimental and Molecular Pathologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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