Mutagenicity of aliphatic epoxides
dc.contributor.author | Wade, D. R. | en_US |
dc.contributor.author | Airy, Subhash C. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-07T16:58:07Z | |
dc.date.available | 2006-04-07T16:58:07Z | |
dc.date.issued | 1978-11 | en_US |
dc.identifier.citation | Wade, D. R., Airy, S. C., Sinsheimer, J. E. (1978/11)."Mutagenicity of aliphatic epoxides." Mutation Research/Genetic Toxicology 58(2-3): 217-223. <http://hdl.handle.net/2027.42/22496> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73FB-478FC6M-67/2/cf42586a67e15c081508c2375997079e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22496 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=370573&dopt=citation | en_US |
dc.description.abstract | The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and TA1535 depended on the degree of substitution around the oxirane ring. Monosubstituted oxiranes were the most potent mutagens in both strains. 1,1-Disubstitution resulted in the complete loss or reduction of mutagenicity. trans-1,2-Disubstituted, and tetrasubstituted oxiranes all lacked mutagenicity, while the cis-1,2-disubstituted oxiranes tested were weakly mutagenic in strain TA100 only. For the monosubstituted compounds the presence of electron-withdrawing substituents increased mutagenicity. | en_US |
dc.format.extent | 384246 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Mutagenicity of aliphatic epoxides | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 370573 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22496/1/0000037.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1218(78)90012-5 | en_US |
dc.identifier.source | Mutation Research/Genetic Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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