Hormonal regulation of ovarian cellular proliferation
dc.contributor.author | Rao, Mrinalini C. | en_US |
dc.contributor.author | Midgley, A. Rees, Jr. | en_US |
dc.contributor.author | Richards, JoAnne S. | en_US |
dc.date.accessioned | 2006-04-07T17:01:25Z | |
dc.date.available | 2006-04-07T17:01:25Z | |
dc.date.issued | 1978-05 | en_US |
dc.identifier.citation | Rao, Mrinalini C., Midgley, Jr., A. Rees, Richards, JoAnne S. (1978/05)."Hormonal regulation of ovarian cellular proliferation." Cell 14(1): 71-78. <http://hdl.handle.net/2027.42/22604> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WSN-4C7WDVJ-6G/2/904b4b1ac0343ea24b145b77507e145b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22604 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=566619&dopt=citation | en_US |
dc.description.abstract | The steroid hormone estradiol, and the glycoprotein hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), are known to be essential for the growth and differentiation of follicles in the ovary. The present study was conducted to determine quantitatively the effects of estradiol, FSH and LH on proliferation of different ovarian cell types (granulosa and theca cells). The immature female hypophysectomized rat sequentially primed with estradiol, FSH and LH was used as the experimental model. Proliferation was assessed by examining changes in total DNA, incorporation of 3H-thymidine into DNA and labeling index in specific cell types. Estradiol and FSH each acted on follicies at different stages of development to stimulate proliferative activity of both granulosa and theca cells. Continued administration of either hormone caused a decrease in the proliferative activity of both cell types. These observations have been interpreted to indicate that estradiol and FSH can each alter the length of the specific phases of the cell cycle. A luteinizing dose of LH caused a cessation of proliferation in luteinizing granulosa cells while stimulating a limited proliferation of theca cells. Absence of the appropriate hormonal stimulus caused both granulosa and theca cells to stop proliferating and the follicles to undergo atresia. These results indicate that, depending upon the state of differentiation of granulosa and theca cells, estradiol, FSH and LH can stimulate or inhibit the ability of these cells to proliferate. | en_US |
dc.format.extent | 3577788 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Hormonal regulation of ovarian cellular proliferation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Reproductive Endocrinology Program Department of Pathology University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Reproductive Endocrinology Program Department of Pathology University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Reproductive Endocrinology Program Department of Pathology University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 566619 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22604/1/0000154.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0092-8674(78)90302-1 | en_US |
dc.identifier.source | Cell | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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