Interactions of partial LSD analogs with behavioral disrupting effects of LSD and DMT in the rat
dc.contributor.author | Kovacic, Beverly | en_US |
dc.contributor.author | Wang Lu, Lee-Jane | en_US |
dc.contributor.author | Ruffing, Diane M. | en_US |
dc.contributor.author | Domino, Edward F. | en_US |
dc.date.accessioned | 2006-04-07T17:04:25Z | |
dc.date.available | 2006-04-07T17:04:25Z | |
dc.date.issued | 1978-01-01 | en_US |
dc.identifier.citation | Kovacic, Beverly, Wang Lu, Lee-Jane, Ruffing, Diane, Domino, Edward F. (1978/01/01)."Interactions of partial LSD analogs with behavioral disrupting effects of LSD and DMT in the rat." European Journal of Pharmacology 47(1): 37-44. <http://hdl.handle.net/2027.42/22701> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-4772PD7-CC/2/a7c82ede013bfb03325e5857e372d7c6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22701 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=271075&dopt=citation | en_US |
dc.description.abstract | Adult male Holtzman rats were trained to barpress on a schedule whereby every fourth press earned a reward of 0.01 ml of sugar-sweetened milk (FR4). After an i.p. injecton of LSD (0.1 mg/kg) or DMT (3.2 or 10 mg/kg) such barpressing is abolished completely and resumed, usually within an hour, at a rate near the preinjection control rate of pressing. It continues at a steady, uninterrupted pace until animals are removed from the operant chamber one-half hour later. A series of N,N-diethylnipecotamide derivatives were synthesized and tested for their ability to modify the disruptive effect of these hallucinogens. N,N-diethylbutyramide (DBA) and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC) were also tested. Pretreatment with a single i.p. injection of any of these compounds (5-40 mg/kg) either had no effect on or else prolonged the duration of hallucinogen-induced cessation of barpressing. | en_US |
dc.format.extent | 523619 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Interactions of partial LSD analogs with behavioral disrupting effects of LSD and DMT in the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Pharmacology, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Pharmacology, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Pharmacology, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Pharmacology, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.identifier.pmid | 271075 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22701/1/0000255.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(78)90371-0 | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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