View Item 

Show simple item record

Mutagenicity of alkyl-([omega]-hydroxyalkyl) nitrosamines related to dibutylnitrosamine

dc.contributor.authorOlajos, Eugene J.en_US
dc.contributor.authorMaverakis, Nick H.en_US
dc.contributor.authorCornish, Herbert H.en_US
dc.date.accessioned2006-04-07T17:05:16Z
dc.date.available2006-04-07T17:05:16Z
dc.date.issued1978-01en_US
dc.identifier.citationOlajos, Eugene J., Maverakis, Nick, Cornish, Herbert H. (1978/01)."Mutagenicity of alkyl-([omega]-hydroxyalkyl) nitrosamines related to dibutylnitrosamine." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 56(3): 219-223. <http://hdl.handle.net/2027.42/22725>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T2C-48HRWFN-13/2/08f2ae19810030a0fe8df31279e7dbf4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22725
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=342939&dopt=citationen_US
dc.description.abstractVarious alkyl-([omega]-hydroxyalkyl) derivatives related to dibutylnitrosamine (DBN) were investigated for mutagenicity in the absence of liver-activation system. Butyl-(4-hydroxybutyl)-, butyl-(3-hydroxypropyl)-, and butyl-(2-hydroxyethyl)-nitrosamines were so tested and found to be mutagenic for TA 1535 strain of Salmonella typhimurium. In all cases, a simple dose-response relationship was observed. Furthermore, no significant (p S. typhimurium by the higher dialkylnitrosamines is partially due to the formation of [omega]-hydroxylated derivatives in addition to the major mutagenic metabolite derived from [alpha]-carbon dealkylation.en_US
dc.format.extent311148 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMutagenicity of alkyl-([omega]-hydroxyalkyl) nitrosamines related to dibutylnitrosamineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Environmental and Industrial Health and Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Mich., U.S.A.en_US
dc.contributor.affiliationumDepartments of Environmental and Industrial Health and Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Mich., U.S.A.en_US
dc.contributor.affiliationumDepartments of Environmental and Industrial Health and Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Mich., U.S.A.en_US
dc.identifier.pmid342939en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22725/1/0000280.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0027-5107(78)90188-4en_US
dc.identifier.sourceMutation Research/Fundamental and Molecular Mechanisms of Mutagenesisen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000280.pdf
Size:
303.8KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.