The effect of various resuscitative regimens on hemorrhagic shock in puppies
dc.contributor.author | Strodel, William E. | en_US |
dc.contributor.author | Callahan, Mark | en_US |
dc.contributor.author | Weintraub, William H. | en_US |
dc.contributor.author | Coran, Arnold G. | en_US |
dc.date.accessioned | 2006-04-07T17:07:34Z | |
dc.date.available | 2006-04-07T17:07:34Z | |
dc.date.issued | 1977-12 | en_US |
dc.identifier.citation | Strodel, William E., Callahan, Mark, Weintraub, William H., Coran, Arnold G. (1977/12)."The effect of various resuscitative regimens on hemorrhagic shock in puppies." Journal of Pediatric Surgery 12(6): 809-819. <http://hdl.handle.net/2027.42/22801> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WKP-4C418F2-X1/2/780c6325fc9251d319e547d4435f80d7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22801 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=592063&dopt=citation | en_US |
dc.description.abstract | Since shock secondary to hemorrhage is not infrequently encountered in the pediatric patient, a puppy model was devised to help measure and monitor cardiovascular and metabolic changes that occur before and after resuscitation from hypovolemic shock (mean arterial pressure of 50 mm Hg for 1 hr). Three resuscitation protocols were compared: whole blood (replacement: shed) 1:1, 5% albumin in Ringer's lactate 1:1, and Ringer's lactate 3:1. All dogs survived the experiment and responded similarly during the shock period. Thermal dilution cardiac output rose in all groups after resuscitation; however, in the Ringer's lactate and 5% albumin groups, cardiac output was statistically greater than that observed in the blood group. In all groups, pH and blood pressure approached but did not return completely to baseline levels after resuscitation. In addition, early resuscitation demonstrated a further decrease in pH ("hidden acidosis") before it began to return toward normal as resuscitation progressed. This study suggests that the infusion of large volumes of Ringer's lactate or 5% albumin in Ringer's lactate are equally efficacious in the treatment of hemorrhage. However, 5% albumin seems to be preferable because it allows infusion of a smaller quantity of electrolyte solution with equivalent physiologic benefits. | en_US |
dc.format.extent | 798985 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effect of various resuscitative regimens on hemorrhagic shock in puppies | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Mich, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Mich, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Mich, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Mich, USA | en_US |
dc.identifier.pmid | 592063 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22801/1/0000358.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-3468(77)90589-9 | en_US |
dc.identifier.source | Journal of Pediatric Surgery | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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