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ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN

dc.contributor.authorRifkin, G. D.en_US
dc.contributor.authorFekety, F. Roberten_US
dc.contributor.authorSilva, Joseph Jr.en_US
dc.contributor.authorSack, R. B.en_US
dc.date.accessioned2006-04-07T17:07:47Z
dc.date.available2006-04-07T17:07:47Z
dc.date.issued1977-11-26en_US
dc.identifier.citationRifkin, G. D., Fekety, F. R., Silva, JR., J., Sack, R. B. (1977/11/26)."ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN." The Lancet 310(8048): 1103-1106. <http://hdl.handle.net/2027.42/22808>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T1B-49NRDK8-166/2/91cc16e4a71715bf98099a4c30d5f908en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22808
dc.description.abstractA toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio choleroe toxins. These characteristics were identical to those of a toxin implicated in the aetiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.en_US
dc.format.extent554042 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXINen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,, U.S.A.en_US
dc.contributor.affiliationumDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,, U.S.A.en_US
dc.contributor.affiliationumDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Medicine, Baltimore City Hospital and Johns Hopkins University, Baltimore, Maryland, United Statesen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22808/1/0000365.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0140-6736(77)90547-5en_US
dc.identifier.sourceThe Lanceten_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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