ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN
dc.contributor.author | Rifkin, G. D. | en_US |
dc.contributor.author | Fekety, F. Robert | en_US |
dc.contributor.author | Silva, Joseph Jr. | en_US |
dc.contributor.author | Sack, R. B. | en_US |
dc.date.accessioned | 2006-04-07T17:07:47Z | |
dc.date.available | 2006-04-07T17:07:47Z | |
dc.date.issued | 1977-11-26 | en_US |
dc.identifier.citation | Rifkin, G. D., Fekety, F. R., Silva, JR., J., Sack, R. B. (1977/11/26)."ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN." The Lancet 310(8048): 1103-1106. <http://hdl.handle.net/2027.42/22808> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1B-49NRDK8-166/2/91cc16e4a71715bf98099a4c30d5f908 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22808 | |
dc.description.abstract | A toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio choleroe toxins. These characteristics were identical to those of a toxin implicated in the aetiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool. | en_US |
dc.format.extent | 554042 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Medicine, Baltimore City Hospital and Johns Hopkins University, Baltimore, Maryland, United States | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22808/1/0000365.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0140-6736(77)90547-5 | en_US |
dc.identifier.source | The Lancet | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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