Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: Similarity to hydrophobic amino-terminal segments of preproteins
dc.contributor.author | Haugen, David A. | en_US |
dc.contributor.author | Armes, Lyman G. | en_US |
dc.contributor.author | Yasunobu, Kerry T. | en_US |
dc.contributor.author | Coon, Minor J. | en_US |
dc.date.accessioned | 2006-04-07T17:09:16Z | |
dc.date.available | 2006-04-07T17:09:16Z | |
dc.date.issued | 1977-08-08 | en_US |
dc.identifier.citation | Haugen, David A., Armes, Lyman G., Yasunobu, Kerry T., Coon, Minor J. (1977/08/08)."Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: Similarity to hydrophobic amino-terminal segments of preproteins." Biochemical and Biophysical Research Communications 77(3): 967-973. <http://hdl.handle.net/2027.42/22857> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4G0VTNW-SG/2/034489db9fb805f24d7869c47e718609 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22857 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=901525&dopt=citation | en_US |
dc.description.abstract | SummaryThe amino-terminal sequence of two electrophoretically homogeneous forms of rabbit liver microsomal cytochrome P-450, P-450LM2 and P-45LM4, has been examined by automated Edman degradation. Methionine is the amino terminus of P-450LM2, and 17 of the first 20 residues are hydrophobic, including two clusters of five consecutive leucines. The composition and sequence of this region are similar to those of the short-lived hydrophobic amino-terminal precursor segments of certain other proteins, especially myeloma immunoglobulin light chains and pancreatic zymogens. Multiple amino-terminal residues, including methionine, were detected for P-450LM4 suggesting the presence of several highly similar forms of P-450 or that partial proteolysis had occurred. | en_US |
dc.format.extent | 407426 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: Similarity to hydrophobic amino-terminal segments of preproteins | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry Medical School, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois 60439, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry and Biophysics, University of Hawaii Medical School, Honolulu, Hawaii 96822, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry and Biophysics, University of Hawaii Medical School, Honolulu, Hawaii 96822, USA | en_US |
dc.identifier.pmid | 901525 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22857/1/0000419.pdf | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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