The stimulation of cerebral N2-methyl- and N22-dimethyl guanine-specific tRNA methyltransferases by methionine sulfoximine: An study
dc.contributor.author | Salas, Carlos E. | en_US |
dc.contributor.author | Ohlsson, W. G. | en_US |
dc.contributor.author | Sellinger, Otto Z. | en_US |
dc.date.accessioned | 2006-04-07T17:10:30Z | |
dc.date.available | 2006-04-07T17:10:30Z | |
dc.date.issued | 1977-06-20 | en_US |
dc.identifier.citation | Salas, C. E., Ohlsson, W. G., Sellinger, O. Z. (1977/06/20)."The stimulation of cerebral N2-methyl- and N22-dimethyl guanine-specific tRNA methyltransferases by methionine sulfoximine: An study." Biochemical and Biophysical Research Communications 76(4): 1107-1115. <http://hdl.handle.net/2027.42/22895> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DNHY4S-T7/2/646602dce9875b70f5e2767a54bbc2a5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/22895 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=332160&dopt=citation | en_US |
dc.description.abstract | The administration of a single convulsant dose or of multiple subconvulsant doses of L-methionine-dl-sulfoximine (MSO) to 18-day old rats results in a significant elevation of the specific activity of cerebral tRNA methyltransferases, as determined in an assay, using heterologous or species-homologous tRNAs as substrates. The increase was detectable as early as 90 min after MSO and persisted throughout the entire 5-6 h preconvulsant period. The 14[C]-methyl tRNA was purified, and hydrolyzed to its constituent bases and their distribution was quantitated by high performance liquid chromatography. A marked increase in the formation of 14[C]-N2-methyl- and 14[C]-N22-dimethyl guanine was noted in the MSO-treated animals, demonstrating a specific stimulation by MSO of the cerebral N2-methyl and/or N22-dimethyl guanine-specific tRNA methyltransferases. | en_US |
dc.format.extent | 470836 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The stimulation of cerebral N2-methyl- and N22-dimethyl guanine-specific tRNA methyltransferases by methionine sulfoximine: An study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry, Mental Health Research Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry, Mental Health Research Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry, Mental Health Research Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 332160 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/22895/1/0000459.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(77)90970-6 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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