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Sensitive radioimmunoassay for digoxin in plasma and urine

dc.contributor.authorWagner, John G.en_US
dc.contributor.authorHallmark, Margarette R.en_US
dc.contributor.authorSakmar, Ermelindaen_US
dc.contributor.authorAyres, James W.en_US
dc.date.accessioned2006-04-07T17:11:11Z
dc.date.available2006-04-07T17:11:11Z
dc.date.issued1977-06en_US
dc.identifier.citationWagner, J. G., Hallmark, M. R., Sakmar, E., Ayres, J. W. (1977/06)."Sensitive radioimmunoassay for digoxin in plasma and urine." Steroids 29(6): 787-807. <http://hdl.handle.net/2027.42/22917>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TC9-47P8XPG-7/2/4d252a1f6fe6e0e6f7c23604d8994958en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/22917
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=910251&dopt=citationen_US
dc.description.abstractA reproducible and sensitive radioimmunoassay for digoxin in either serum, plasma or urine is described. Using 0.5 ml of serum or plasma, the assay sensitivity is 0.05 ng of digoxin/ml. The antiserum and tracer solutions employed are available in a kit sold in the United States. All other reagents were prepared in the laboratory. The assay allows measurement of digoxin in plasma or serum for 96 hours after single 0.5 mg doses of digoxin; this is necessary in human bioavailability studies to accurately estimate the total area under the digoxin concentration, time curve from zero to infinite time. In contrast, with the kit assay, employing 0.2 ml of plasma or serum, it has been reported that the 12 hr serum digoxin levels, after single 0.5 mg doses, are, in most subjects, below the sensitivity limit (about 0.5 ng/ml) of the assay.en_US
dc.format.extent1388363 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSensitive radioimmunoassay for digoxin in plasma and urineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy and Upjohn Center for Clinical Pharmacology The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumCollege of Pharmacy and Upjohn Center for Clinical Pharmacology The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumCollege of Pharmacy and Upjohn Center for Clinical Pharmacology The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumSchool of Pharmacy, Oregon State University, Corvallis, Oregon 97331; College of Pharmacy and Upjohn Center for Clinical Pharmacology The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid910251en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/22917/1/0000482.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0039-128X(77)90122-2en_US
dc.identifier.sourceSteroidsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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