The genetic implications of age-dependent penetrance in manic-depressive illness
dc.contributor.author | Crowe, Raymond R. | en_US |
dc.contributor.author | Smouse, Peter E. | en_US |
dc.date.accessioned | 2006-04-07T17:15:08Z | |
dc.date.available | 2006-04-07T17:15:08Z | |
dc.date.issued | 1977 | en_US |
dc.identifier.citation | Crowe, Raymond R., Smouse, Peter E. (1977)."The genetic implications of age-dependent penetrance in manic-depressive illness." Journal of Psychiatric Research 13(4): 273-285. <http://hdl.handle.net/2027.42/23042> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T8T-461T1DY-34/2/b54956c688989576a43412d5ecd2a8a1 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23042 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=606810&dopt=citation | en_US |
dc.description.abstract | An age dependent penetrance function was derived for manic-depressive illness, using age-of-onset data from sixty-one affected probands. The function used was a one-hit model, with earliest age-of-onset at about 14 yr, and a steadily increasing probability of manifesting the illness thereafter. The utility of the penetrance function for pedigree analysis was illustrated, using the families of the sixty-one probands. A sex-linked dominant model of inheritance was about eighty-nine times more likely than an autosomal dominant model, and both were far more likely than autosomal recessive or sex-linked recessive models. The more general single major locus model and the polygenic model cannot be ruled out, but would seem to be unnecessarily over-parameterized for the data at hand. The sex-linked dominant and autosomal dominant models were also compared, by means of the age specific morbidity risks and sibs and children. Both models provided a fairly close fit of expectation and observation, but the sex-linked model was preferable. Although the genetic conclusions cannot automatically be applied to other material, the analytical techniques should be useful elsewhere. Other uses of the penetrance function were indicated. | en_US |
dc.format.extent | 1020039 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The genetic implications of age-dependent penetrance in manic-depressive illness | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of Iowa, College of Medicine, Iowa City, IA 52242, U.S.A. | en_US |
dc.identifier.pmid | 606810 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23042/1/0000614.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-3956(77)90015-2 | en_US |
dc.identifier.source | Journal of Psychiatric Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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