Connective tissue activation. XVII. Radioimmunoassay of a human platelet derived connective tissue activating peptide (CTAP-III) and specificities of anti-CTAP-III sera
dc.contributor.author | Weiss, John Jay | en_US |
dc.contributor.author | Meyers, Stephen | en_US |
dc.contributor.author | Castor, C. William | en_US |
dc.contributor.author | Donakowski, Caroline | en_US |
dc.contributor.author | Anderson, Byron E. | en_US |
dc.date.accessioned | 2006-04-07T17:19:44Z | |
dc.date.available | 2006-04-07T17:19:44Z | |
dc.date.issued | 1980-12-22 | en_US |
dc.identifier.citation | Weiss, John Jay, Meyers, Stephen, Castor, C. William, Donakowski, Caroline, Anderson, Byron (1980/12/22)."Connective tissue activation. XVII. Radioimmunoassay of a human platelet derived connective tissue activating peptide (CTAP-III) and specificities of anti-CTAP-III sera." Clinica Chimica Acta 108(3): 425-433. <http://hdl.handle.net/2027.42/23085> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T57-47RS679-14P/2/3fad7bd07d12bc8af32a36946086a6dd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23085 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7471473&dopt=citation | en_US |
dc.description.abstract | The platelet-derived connective tissue activating peptide (CTAP-III) has been shown to be an important factor stimulating the metabolism and proliferation of human connective tissue cell strains, including synovial tissue cells. The quantities of CTAP-III affecting the cellular changes and the amounts in various biologic fluids and tissues are small. The objectives of this study were to develop a radioimmunoassay (RIA) for CTAP-III and to ascertain the specificities of the anti-CTAP-III sera reagents. The antisera were shown not to cross-react with a number of polypeptide hormones. However, two other platelet proteins, [beta]-thromboglobulin and low affinity platelet factor-4, competed equally as well as CTAP-III for anti-CTAP-III antibodies in the RIA system. Thus, the three platelet proteins are similar or identical with respect to those portions of the molecules constituting the reactive antigenic determinants. The levels of material in normal human platelet-free plasma that inhibited anti-CTAP-III-12S!-CTAP-III complex formation were determined to be 34 +/- 13 (S.D.) ng/ml. | en_US |
dc.format.extent | 719775 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Connective tissue activation. XVII. Radioimmunoassay of a human platelet derived connective tissue activating peptide (CTAP-III) and specificities of anti-CTAP-III sera | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan School of Medicine, Chicago, IL 60G11, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan School of Medicine, Chicago, IL 60G11, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Clinical Pathology, Northwestern University Medical School, Chicago, IL 60G11, U.S.A. | en_US |
dc.contributor.affiliationother | Departments of Biochemistry and Otolaryngology and Maxillofacial Surgery, Northwestern University Medical School, Chicago, IL 60G11, U.S.A. | en_US |
dc.contributor.affiliationother | Departments of Biochemistry and Otolaryngology and Maxillofacial Surgery, Northwestern University Medical School, Chicago, IL 60G11, U.S.A. | en_US |
dc.identifier.pmid | 7471473 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23085/1/0000002.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0009-8981(80)90350-2 | en_US |
dc.identifier.source | Clinica Chimica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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