Lymphocyte cytotoxicity in human liver disease using rat hepatocyte monolayer cultures
dc.contributor.author | Mutchnick, Milton G. | en_US |
dc.contributor.author | Missirian, Araxie | en_US |
dc.contributor.author | Johnson, Arthur G. | en_US |
dc.date.accessioned | 2006-04-07T17:22:54Z | |
dc.date.available | 2006-04-07T17:22:54Z | |
dc.date.issued | 1980-08 | en_US |
dc.identifier.citation | Mutchnick, Milton G., Missirian, Araxie, Johnson, Arthur G. (1980/08)."Lymphocyte cytotoxicity in human liver disease using rat hepatocyte monolayer cultures." Clinical Immunology and Immunopathology 16(4): 423-437. <http://hdl.handle.net/2027.42/23186> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-4BJW1VV-NK/2/dce8ae8f7f34ebed07118cffd247ec1f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23186 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7408232&dopt=citation | en_US |
dc.description.abstract | Isolated rat hepatocytes were used to determine the cytotoxicity of peripheral blood mononuclear cells (PBM) from patients with alcoholic liver disease (ALD) and chronic active hepatitis (CAH). The specificity of the cytotoxic effect on liver cells was monitored using rat kidney cells. PBM from patients with CAH and ALD showed increased spontaneous cell-mediated cytolysis (SCMC) for hepatocytes. The SCMC against kidney cells was comparable for the patient groups and controls. Incubation of liver cells with antibody to human liver-specific protein significantly increased the cytotoxic activity of control PBM but did not block cytotoxicity by PBM of patients with CAH. Incubation of PBM from untreated CAH patients with thymosin fraction 5, a polypeptide extract of the thymus gland, significantly lowered cytotoxicity. Our findings suggest that rat liver cells provide a model for studies of cell-mediated immunity in human liver disease and that thymosin fraction 5 decreases the cytotoxic activity of sensitized lymphocytes in CAH. | en_US |
dc.format.extent | 1044737 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Lymphocyte cytotoxicity in human liver disease using rat hepatocyte monolayer cultures | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology, University of Michigan, Ann Arbor, Michigan 48105, USA; Research Service, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA; Department of Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA. | en_US |
dc.contributor.affiliationum | Department of Microbiology, University of Michigan, Ann Arbor, Michigan 48105, USA; Research Service, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA; Department of Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA. | en_US |
dc.contributor.affiliationum | Department of Microbiology, University of Michigan, Ann Arbor, Michigan 48105, USA; Research Service, Veterans Administration Medical Center, Ann Arbor, Michigan 48105, USA; Department of Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA. | en_US |
dc.identifier.pmid | 7408232 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23186/1/0000113.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-1229(80)90184-1 | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.