Zinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin B
dc.contributor.author | Rao, K. Murali Krishna | en_US |
dc.contributor.author | Schwartz, Stanley A. | en_US |
dc.date.accessioned | 2006-04-07T17:22:59Z | |
dc.date.available | 2006-04-07T17:22:59Z | |
dc.date.issued | 1980-08 | en_US |
dc.identifier.citation | Rao, K. Murali Krishna, Schwartz, Stanley A. (1980/08)."Zinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin B." Clinical Immunology and Immunopathology 16(4): 463-473. <http://hdl.handle.net/2027.42/23189> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-4BJW1VV-NR/2/bf7d628b9fdbf7f886cabd6df1e00101 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23189 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6773708&dopt=citation | en_US |
dc.description.abstract | We have previously reported that zinc affects the mitogenic process in an age-dependent fashion when added to lectin-stimulated lymphocytes. The present studies demonstrate an additional selective effect of zinc when added to Con A-activated lymphocytes plus pharmacologic agents known to affect the cytoskeleton or the permeability of the plasma membrane. Specifically, addition of zinc did not modulate the dose-dependent activities of Ca2+ ionophore A23187, nigericin, or colchicine demonstrating that the immunologic effects of zinc do not involve modification of Ca2+ or K+ fluxes, or microtubule formation. By contrast, a consistent and reproducible shift in the cytochalasin B dose-response curve of lymphocytes stimulated by Con A was observed when zinc was added. These data indicate that the effect of zinc on immune functions may be operating through cytochalasin B-sensitive subcellular structures, most likely microfilaments. | en_US |
dc.format.extent | 634835 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Zinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin B | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 6773708 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23189/1/0000116.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-1229(80)90188-9 | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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