The UPS locus encoding uroporphyrinogen I synthase is located on human chromosome 11
dc.contributor.author | Meisler, Miriam H. | en_US |
dc.contributor.author | Wanner, L. | en_US |
dc.contributor.author | Eddy, R. E. | en_US |
dc.contributor.author | Shows, Thomas B. | en_US |
dc.date.accessioned | 2006-04-07T17:23:16Z | |
dc.date.available | 2006-04-07T17:23:16Z | |
dc.date.issued | 1980-07-16 | en_US |
dc.identifier.citation | Meisler, M., Wanner, L., Eddy, R. E., Shows, T. B. (1980/07/16)."The UPS locus encoding uroporphyrinogen I synthase is located on human chromosome 11." Biochemical and Biophysical Research Communications 95(1): 170-176. <http://hdl.handle.net/2027.42/23198> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DN95M1-YP/2/c20b4117a02927fb0dc99c7bdde67408 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23198 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7417246&dopt=citation | en_US |
dc.description.abstract | The expression of the UPS locus encoding uroporphyrinogen I synthase has been investigated in human/mouse somatic cell hybrids. Human and mouse uroporphyrinogen I synthase can be readily distinguished by their isoelectric points. In hybrid cells, both human and mouse isozymes are detected. The multiple human uroporphyrinogen I synthase isozymes segregate as a single unit, as expected if they are the products of a single locus. The absence of new heteropolymers in hybrid cells supports the biochemical evidence that the active enzyme is a monomer. The presence of human uroporphyrinogen I synthase in hybrid clones was correlated with the presence of human chromosome 11, or its enzymatic marker, without exception in 44 independent hybrid lines. All other chromosomes could be eliminated as possible locations for this locus, due to their independent segregation. This report represents the first gene assignment for an enzyme in the heme biosynthesis pathway. | en_US |
dc.format.extent | 664755 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The UPS locus encoding uroporphyrinogen I synthase is located on human chromosome 11 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Biochemical Genetics Section, Roswell Park Memorial Institute, Buffalo, New York 14263, USA | en_US |
dc.contributor.affiliationother | Biochemical Genetics Section, Roswell Park Memorial Institute, Buffalo, New York 14263, USA | en_US |
dc.identifier.pmid | 7417246 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23198/1/0000125.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(80)90719-6 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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