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Conjugation of triaziquinone to immunoglobulin G by a thiolation procedure catalyzed by 2-pyridinealdoxime methiodide
dc.contributor.authorWarzynski, Michael J. S.en_US
dc.contributor.authorCochran, Kenneth W.en_US
dc.contributor.authorWilbur Ackermann, W.en_US
dc.date.accessioned2006-04-07T17:23:22Z
dc.date.available2006-04-07T17:23:22Z
dc.date.issued1980-07-15en_US
dc.identifier.citationWarzynski, Michael J. S., Cochran, Kenneth W., Wilbur Ackermann, W. (1980/07/15)."Conjugation of triaziquinone to immunoglobulin G by a thiolation procedure catalyzed by 2-pyridinealdoxime methiodide." Journal of Immunological Methods 35(1-2): 157-168. <http://hdl.handle.net/2027.42/23201>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T2Y-476KVWY-1KX/2/429c5ec6a8e2eca156e29afcea5c9cdeen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23201
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7204987&dopt=citationen_US
dc.description.abstractThiolation of immunoglobulin G (IgG) with -N-acetylhomocycteinethiolactone, catalyzed by 2-pyridinealdoxime methiodide, incorporated new sulfur groups into IgG. Triaziquinone was subsequently conjugated to the sulfur groups. Triaziquinone-IgG complex retained the alkylating activity of the drug and the immunological activity of the antibody. The conjugation procedure was inhibited by the thiol-blocking agent methyl methanethiolsulfonate.en_US
dc.format.extent745957 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleConjugation of triaziquinone to immunoglobulin G by a thiolation procedure catalyzed by 2-pyridinealdoxime methiodideen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid7204987en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23201/1/0000128.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-1759(80)90160-Xen_US
dc.identifier.sourceJournal of Immunological Methodsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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