Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules
dc.contributor.author | Parkinson, A. | en_US |
dc.contributor.author | Robertson, L. W. | en_US |
dc.contributor.author | Safe, Lorna | en_US |
dc.contributor.author | Safe, S. | en_US |
dc.date.accessioned | 2006-04-07T17:24:14Z | |
dc.date.available | 2006-04-07T17:24:14Z | |
dc.date.issued | 1980-06 | en_US |
dc.identifier.citation | Parkinson, A., Robertson, L., Safe, Lorna, Safe, S. (1980/06)."Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules." Chemico-Biological Interactions 30(3): 271-285. <http://hdl.handle.net/2027.42/23229> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T56-475JG4Y-7B/2/9f11120768d0ca84b16bdc5597108092 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23229 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6769597&dopt=citation | en_US |
dc.description.abstract | A number of highly purified polychlorinated biphenyl (PCB) isomers and congeners were synthesized and administered to male Wistar rats at dosage levels of 30 and 150 [mu]mol [middle dot] kg-1. The effects of this in vivo treatment on the drug-metabolizing enzymes were determined by measuring the microsomal benzo[a]pyrene (B[a]P) hydroxylase, dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase enzyme activities, the cytochrome b5 content and the relative peak intensities and spectral shifts of the reduced microsomal cytochrome P-450: CO and ethylisocyanide (EIC) binding difference spectra. The results were compared to the effects of administering phenobarbitone (PB), 3-methylcholanthrene (MC) and PB plus MC (coadministered) to the test animals. The synthetic PCB congeners used in this study included 3,4,4',5-tetrachlorobiphenyl (TCBP-1), 2,3',4,4'-tetrachlorobiphenyl (TCBP-2), 2,3',4,4',5'-pentachlorobiphenyl (PCBP-1), 2,3,4,4',5-pentachlorobiphenyl (PCBP-2), 2,3,3',4,4',5-hexachlorobiphenyl (HCBP-1), 2,3,3',4',5,6-hexachlorobiphenyl (HCBP-2), 2,3,3',5,5',6-hexachlorobiphenyl (HCBP-3), 2,2',3,5,5',6-hexachlorobiphenyl (HCBP-4) and 2,3,3',4,5,5'-hexachlorobiphenyl (HCBP-5) and were used to reappraise the structure-activity rules for PCBs as hepatic microsomal enzyme inducers. The results suggested that (a) PCBs which induce MC or mixed-type activity must be substituted at both para positions, at least two meta positions but not necessarily on the same phenyl ring and can also contain one ortho chloro substituent; (b) due to the considerable structural diversity of the PB-type inducers the rules for induction of this activity by PCB congeners are not readily defined. | en_US |
dc.format.extent | 948203 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | School of Public Health, The University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, N1G 2W1, Canada | en_US |
dc.identifier.pmid | 6769597 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23229/1/0000162.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0009-2797(80)90050-2 | en_US |
dc.identifier.source | Chemico-Biological Interactions | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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