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Binding of 3H-[beta]-endorphin to rat brain membranes: Characterization of opiate properties and interaction with ACTH
dc.contributor.authorAkil, Hudaen_US
dc.contributor.authorHewlett, William A.en_US
dc.contributor.authorBarchas, Jack D.en_US
dc.contributor.authorChoh Hao Li,en_US
dc.date.accessioned2006-04-07T17:24:33Z
dc.date.available2006-04-07T17:24:33Z
dc.date.issued1980-05-30en_US
dc.identifier.citationAkil, Huda, Hewlett, William A., Barchas, Jack D., Choh Hao Li, (1980/05/30)."Binding of 3H-[beta]-endorphin to rat brain membranes: Characterization of opiate properties and interaction with ACTH." European Journal of Pharmacology 64(1): 1-8. <http://hdl.handle.net/2027.42/23239>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T1J-4772P2T-7N/2/16e106fb40638476c0491d24a1e14e29en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23239
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6256172&dopt=citationen_US
dc.description.abstractThe binding of tritiated [beta]-endorphin (3H-[beta]-EP) to brain homogenates is described. This had been difficult to achieve due to the lack of availability of 3H-[beta]-EP and to technical difficulties associated with high non-specific binding of [beta]-EP. We now report that 3H-[beta]-EP binding is saturable, stereospecific, has high affinity and is inhibited by sodium. Its dissociation rate is ten-fold longer than that of naloxone. Its regional distribution exhibits interesting differences from naloxone and enkephalin binding. ACTH1-24 appears to displace it more effectively than it displaces 3H-naloxone. The results are discussed in terms of multiple transmitter systems and the multiple opiate receptor hypothesis.en_US
dc.format.extent540683 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBinding of 3H-[beta]-endorphin to rat brain membranes: Characterization of opiate properties and interaction with ACTHen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherNancy Pritzker Laboratory of Behavioral Neurochemistry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USAen_US
dc.contributor.affiliationotherHormone Research Laboratory, University of California, San Francisco, California 94148, U.S.A.: Nancy Pritzker Laboratory of Behavioral Neurochemistry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USAen_US
dc.identifier.pmid6256172en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23239/1/0000172.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-2999(80)90363-5en_US
dc.identifier.sourceEuropean Journal of Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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