Base-exchange reactions of the phospholipids in cardiac membranes
dc.contributor.author | Filler, David A. | en_US |
dc.contributor.author | Weinhold, Paul A. | en_US |
dc.date.accessioned | 2006-04-07T17:24:34Z | |
dc.date.available | 2006-04-07T17:24:34Z | |
dc.date.issued | 1980-05-28 | en_US |
dc.identifier.citation | Filler, David A., Weinhold, Paul A. (1980/05/28)."Base-exchange reactions of the phospholipids in cardiac membranes." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 618(2): 223-230. <http://hdl.handle.net/2027.42/23240> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1X-47GGJYW-5/2/af335a7e74abe80f448bd34af96213d6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23240 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6769494&dopt=citation | en_US |
dc.description.abstract | Canine cardiac microsomes were shown to incorporate the nitrogenous bases, serine, ethanolamine, and choline, into their respective phospholipids by the energy-independent, Ca2+-stimulated base-exchange reactions. The optimal Ca2+ concentration was 2.5 mM. Metal ions other than Ca2+ either inhibited or had no effect on the activities. La3+ and Mn2+ were both potent inhibitors. The pH optimum for the reactions at 2.5 mM Ca2+ was approx. 7.8 and depended upon Ca2+ concentration. Apparent Km values at 2.5 mM Ca2+ were 0.06 mM for -serine, 0.13 mM for ethanolamine and 0.49 mM for choline. The kinetic and metal ion inhibition studies suggest that the choline-exchange reaction is a separate process from the serine and ethanolamine reactions. The ATPstimulated Ca2+ binding system of the cardiac membranes was not related to the base-exchange reactions; however, the energy-independent Ca2+ binding to the membranes appears to be related to the exchange reactions. | en_US |
dc.format.extent | 637136 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Base-exchange reactions of the phospholipids in cardiac membranes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan Medical School, 2215 Fuller Road, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center and Department of Biological Chemistry, University of Michigan Medical School, 2215 Fuller Road, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.identifier.pmid | 6769494 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23240/1/0000173.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0005-2760(80)90028-4 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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