Etiologic role of lactic dehydrogenase virus infection in an age-dependent neuroparalytic disease in C58 mice
dc.contributor.author | Nawrocki, John F. | en_US |
dc.contributor.author | Pease, Larry R. | en_US |
dc.contributor.author | Murphy, William H. | en_US |
dc.date.accessioned | 2006-04-07T17:25:00Z | |
dc.date.available | 2006-04-07T17:25:00Z | |
dc.date.issued | 1980-05 | en_US |
dc.identifier.citation | Nawrocki, John F., Pease, Larry R., Murphy, William H. (1980/05)."Etiologic role of lactic dehydrogenase virus infection in an age-dependent neuroparalytic disease in C58 mice." Virology 103(1): 259-264. <http://hdl.handle.net/2027.42/23254> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXR-4BNMMNR-7H/2/7b08b537c781e88b738abcf2411303b6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23254 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6892742&dopt=citation | en_US |
dc.description.abstract | Lactic dehydrogenase virus (LDV) associated with transplantable line Ib lymphocytic leukemia in C58/Wm mice, K36 lymphocytic leukemia in AKR/J mice, and the Gardner lymphosarcoma in C3H/HeJ mice elicited a fatal neuroparalytic disease when injected ip into 7- to 9-month-old X-irradiated indicator C58 mice. LDV associated with the WEHI-3B line of transplantable myelomonocytic leukemia or the Harding-Passey transplantable myeloma in BALB/c mice failed to elicit the disease. Recipients of such tumor extracts were immune to rechallenge by line Ib-associated LDV. Tumor lines free of LDV failed to elicit the disease or immunize recipient mice to line Ib LDV challenge. The Plagemann (P-LDV), Riley (R-LDV), and Notkins (N-LDV) strains of LDV were less neuropathogenic than the line Ib-derived strain (Ib-LDV). Indicator C58 mice that survived infection by the P-LDV, R-LDV, and N-LDV strains were immune to rechallenge by Ib-LDV. Antiserum prepared in young C58 mice to Ib-LDV or R-LDV protected indicator C58 mice from Ib-LDV challenge. These results show that a common viral contaminant of transplantable tumors and virus stocks that ordinarily is not pathogenic elicits a fatal neurologic disease in genetically susceptible, immunosuppressed, C58 mice. | en_US |
dc.format.extent | 517767 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Etiologic role of lactic dehydrogenase virus infection in an age-dependent neuroparalytic disease in C58 mice | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Department of Microbiology and Immunology, The University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | The Department of Microbiology and Immunology, The University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | The Department of Microbiology and Immunology, The University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 6892742 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23254/1/0000187.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0042-6822(80)90147-6 | en_US |
dc.identifier.source | Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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