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Synthesis of potential antiprogestins II

dc.contributor.authorBeyer, Bernardoen_US
dc.contributor.authorTerenius, Larsen_US
dc.contributor.authorCounsell, Raymond E.en_US
dc.date.accessioned2006-04-07T17:25:07Z
dc.date.available2006-04-07T17:25:07Z
dc.date.issued1980-05en_US
dc.identifier.citationBeyer, Bernardo, Terenius, Lars, Counsell, Raymond E. (1980/05)."Synthesis of potential antiprogestins II." Steroids 35(5): 481-488. <http://hdl.handle.net/2027.42/23258>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TC9-4FN713R-G/2/acae5b24af0062dec989fb1652acc660en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23258
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7394854&dopt=citationen_US
dc.description.abstractAlkylated derivatives of 17-acetoxyprogesterone were prepared in order to test the hypothesis that bulky groups in certain positions of the steroid molecule have the effect of transforming progestogens into antiprogestogens. These groups might exert binding influence outside the area occupied by progesterone itself. The compounds were tested for competitive affinity against tritiated progesterone and receptor from rabbit uterus cytosol. The low affinity of all derivatives makes it unlikely that they would be active as antiprogestational agents.en_US
dc.format.extent297528 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSynthesis of potential antiprogestins IIen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109, U.S.A.: Department of Medicinal Pharmacology, University of Uppsala, Uppsala, Swedenen_US
dc.contributor.affiliationumLaboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109, U.S.A.: Department of Medicinal Pharmacology, University of Uppsala, Uppsala, Swedenen_US
dc.contributor.affiliationumLaboratory of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109, U.S.A.: Department of Medicinal Pharmacology, University of Uppsala, Uppsala, Swedenen_US
dc.identifier.pmid7394854en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23258/1/0000191.pdfen_US
dc.identifier.sourceSteroidsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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