Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain
dc.contributor.author | Rao Vunnam, Ranga | en_US |
dc.contributor.author | Radin, Norman S. | en_US |
dc.date.accessioned | 2006-04-07T17:25:50Z | |
dc.date.available | 2006-04-07T17:25:50Z | |
dc.date.issued | 1980-04 | en_US |
dc.identifier.citation | Rao Vunnam, Ranga, Radin, Norman S. (1980/04)."Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain." Chemistry and Physics of Lipids 26(3): 265-278. <http://hdl.handle.net/2027.42/23277> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2N-47MCKDF-X/2/01acc882531476defa5171a451838918 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23277 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6445239&dopt=citation | en_US |
dc.description.abstract | In a search for potent inhibitors of glucocerebroside biosynthesis, we synthesized aromatic analogs of the enzyme's substrate, ceramide, many of which have not previously been described in the literature. Mouse brain and spleen, rat brain, and human placenta and spleen were all found to be susceptible to inhibition by a variety of compounds, although to differing extents. The most potent inhibitor was 2-decanoylamino-3-morpholino-1-phenylpropanol. The dehydro version of this compound (2-decanoylamino-3-morpholinopropiophenone) was less effective but it produced inactivation of the enzyme, probably by covalent reaction with the enzyme's active site. Examination of the various effects seen leads us to suggest that the active region of the enzyme contains four recognitional sites: an anionic moiety that may bind the glucose in activated form, an oxygen-binding region oriented toward the third carbon atom of ceramide, a narrow region that binds the alkyl chain of the fatty acid moiety, and a less narrow region that binds the hydrocarbon chain of the sphingoid base moiety. | en_US |
dc.format.extent | 675325 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute (Department of Psychiatry) and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute (Department of Psychiatry) and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6445239 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23277/1/0000214.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0009-3084(80)90057-2 | en_US |
dc.identifier.source | Chemistry and Physics of Lipids | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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