Purine metabolism during strenuous muscular exercise in man
dc.contributor.author | Sutton, John R. | en_US |
dc.contributor.author | Toews, Cornelius J. | en_US |
dc.contributor.author | Ward, Graham R. | en_US |
dc.contributor.author | Fox, Irving H. | en_US |
dc.date.accessioned | 2006-04-07T17:26:41Z | |
dc.date.available | 2006-04-07T17:26:41Z | |
dc.date.issued | 1980-03 | en_US |
dc.identifier.citation | Sutton, John R., Toews, Cornelius J., Ward, Graham R., Fox, Irving H. (1980/03)."Purine metabolism during strenuous muscular exercise in man." Metabolism 29(3): 254-260. <http://hdl.handle.net/2027.42/23305> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WN4-4C836C0-29/2/d8629f7206d935f50796c95324df1126 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23305 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7374440&dopt=citation | en_US |
dc.description.abstract | This study was designed to examine the influence of exercise on purine metabolism in man. In 15 men, the plasma uric acid concentration increased from 6.9 to 8.5 mg/dl following a 5000-m race and from 6.2 to 7.9 mg/dl in 11 men following a 42-km marathon. During a progressive exercise test on a cycle ergometer, the plasma uric acid concentration did not change significantly in 11 subjects. However, the plasma oxypurines increased from 19 [mu]M at rest to 50 [mu]M at exhaustion and the urinary excretion of oxypurines increased from 140 to 400 [mu]mol/g creatinine. Intracellular ATP decreased from 5.17 to 2.91 [mu]mol/g and ADP and AMP increased from 0.85 to 1.29 and from 0.12 to 0.15 [mu]mol/g wet weight, respectively. These observations suggest that there is an accelerated degradation of purine nucleotides to the precursors of uric acid in skeletal muscle during vigorous exercise. | en_US |
dc.format.extent | 665061 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Purine metabolism during strenuous muscular exercise in man | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada; University of Michigan, Ann Arbor, Mich., USA. | en_US |
dc.contributor.affiliationum | Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada; University of Michigan, Ann Arbor, Mich., USA; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. | en_US |
dc.contributor.affiliationum | Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada; University of Michigan, Ann Arbor, Mich., USA; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. | en_US |
dc.contributor.affiliationum | Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada; University of Michigan, Ann Arbor, Mich., USA; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. | en_US |
dc.identifier.pmid | 7374440 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23305/1/0000243.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0026-0495(80)90067-0 | en_US |
dc.identifier.source | Metabolism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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