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Solubilization and chromatographic separation of gonadotrop in receptor from adenylate cyclase in ovarian preparations
dc.contributor.authorSen, K. K.en_US
dc.contributor.authorMenon, K. M. J.en_US
dc.date.accessioned2006-04-07T17:26:53Z
dc.date.available2006-04-07T17:26:53Z
dc.date.issued1980-02-27en_US
dc.identifier.citationSen, K. K., Menon, K. M. J. (1980/02/27)."Solubilization and chromatographic separation of gonadotrop in receptor from adenylate cyclase in ovarian preparations." Biochemical and Biophysical Research Communications 92(4): 1250-1257. <http://hdl.handle.net/2027.42/23312>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DMXFBS-28H/2/60b7fcc5dd6a64aca2b0a61fa8c239d1en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23312
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6245649&dopt=citationen_US
dc.description.abstractThe distribution of gonadotropin receptor and adenylate cyclase activities has been monitored in Sepharose 6B chromatographic eluates of a Lubrol solubilized fraction of 25 day old rat ovarian tissue. The receptor was resolved from the adenylate cyclase activity. Chromatography of a gonadotropin desensitized rat ovarian preparation showed that the desensitized preparation contained normal amounts of the adenylate cyclase activity when compared with the control ovarian preparation, but there was a marked reduction in the receptor activity in the desensitized ovaries. This study demonstrates that in ovarian tissue adenylate cyclase is a separate entity distinct from the receptor molecule and that the desensitization causes a reduction in the receptor activity with no detectable change in the catalytic and chromatographic properties of the adenylate cyclase.en_US
dc.format.extent440681 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSolubilization and chromatographic separation of gonadotrop in receptor from adenylate cyclase in ovarian preparationsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Endocrine Laboratory Department of Obstetrics and Gynecology The University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumEndocrine Laboratory Department of Obstetrics and Gynecology The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biological Chemistry The University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid6245649en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23312/1/0000251.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(80)90421-0en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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