Solubilization and chromatographic separation of gonadotrop in receptor from adenylate cyclase in ovarian preparations
dc.contributor.author | Sen, K. K. | en_US |
dc.contributor.author | Menon, K. M. J. | en_US |
dc.date.accessioned | 2006-04-07T17:26:53Z | |
dc.date.available | 2006-04-07T17:26:53Z | |
dc.date.issued | 1980-02-27 | en_US |
dc.identifier.citation | Sen, K. K., Menon, K. M. J. (1980/02/27)."Solubilization and chromatographic separation of gonadotrop in receptor from adenylate cyclase in ovarian preparations." Biochemical and Biophysical Research Communications 92(4): 1250-1257. <http://hdl.handle.net/2027.42/23312> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DMXFBS-28H/2/60b7fcc5dd6a64aca2b0a61fa8c239d1 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23312 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6245649&dopt=citation | en_US |
dc.description.abstract | The distribution of gonadotropin receptor and adenylate cyclase activities has been monitored in Sepharose 6B chromatographic eluates of a Lubrol solubilized fraction of 25 day old rat ovarian tissue. The receptor was resolved from the adenylate cyclase activity. Chromatography of a gonadotropin desensitized rat ovarian preparation showed that the desensitized preparation contained normal amounts of the adenylate cyclase activity when compared with the control ovarian preparation, but there was a marked reduction in the receptor activity in the desensitized ovaries. This study demonstrates that in ovarian tissue adenylate cyclase is a separate entity distinct from the receptor molecule and that the desensitization causes a reduction in the receptor activity with no detectable change in the catalytic and chromatographic properties of the adenylate cyclase. | en_US |
dc.format.extent | 440681 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Solubilization and chromatographic separation of gonadotrop in receptor from adenylate cyclase in ovarian preparations | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Endocrine Laboratory Department of Obstetrics and Gynecology The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Endocrine Laboratory Department of Obstetrics and Gynecology The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biological Chemistry The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 6245649 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23312/1/0000251.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(80)90421-0 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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