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Cerebellar tRNA methyltransferases: A development study

dc.contributor.authorDainat, Jacquesen_US
dc.contributor.authorSellinger, Otto Z.en_US
dc.date.accessioned2006-04-07T17:27:04Z
dc.date.available2006-04-07T17:27:04Z
dc.date.issued1980-02-03en_US
dc.identifier.citationDainat, Jacques, Sellinger, Otto Z. (1980/02/03)."Cerebellar tRNA methyltransferases: A development study." Brain Research 183(1): 135-143. <http://hdl.handle.net/2027.42/23318>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-4847RJJ-Y8/2/a375b61f369eebb290a47a98dba41c6cen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23318
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7357399&dopt=citationen_US
dc.description.abstractDevelopmental patterns of homologous and heterologous tRNA methylation by cerebellar tRNA methyltransferases are described. The study revealed that: (a) homologous tRNA methylation results in the predominant formation of N2-methyl-guanine and 1-methyladenine; (b) tRNA methyltransferases of bulk-isolated Purkinje and granule cells methylate E. coli tRNAglu2 in vitro in a characteristic manner, and (c) the methylation of 8-day-old cerebellar, cortical and hepatic tRNA in vivo yields tRNAs containing different proportions of methylated bases. The findings suggest that the presumably cell-specific populations of cerebellar tRNA methyltransferases continue to alter their substrate recognition characteristics up to and beyond the first month of post-natal life.en_US
dc.format.extent483370 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCerebellar tRNA methyltransferases: A development studyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Mich. 48109, U.S.A.; Present address: Laboratoire de Neuroendocrinologie, Université des Sciences et Techniques du Languedoc, Montpellier, Cedex 34, France.en_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Mich. 48109, U.S.A.en_US
dc.identifier.pmid7357399en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23318/1/0000257.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(80)90125-0en_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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