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Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster
dc.contributor.authorRobertson, L. W.en_US
dc.contributor.authorParkinson, A.en_US
dc.contributor.authorSafe, S.en_US
dc.date.accessioned2006-04-07T17:27:41Z
dc.date.available2006-04-07T17:27:41Z
dc.date.issued1980-01-15en_US
dc.identifier.citationRobertson, L. W., Parkinson, A., Safe, S. (1980/01/15)."Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster." Biochemical and Biophysical Research Communications 92(1): 175-182. <http://hdl.handle.net/2027.42/23338>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DNJ2F3-1S3/2/e0f29031f0ee875d06d91652c09c6689en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23338
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6243934&dopt=citationen_US
dc.description.abstractThe synthesis and purification of a component of fireMaster BP-6 and fireMaster FF-1, 2,3',4,4',5-pentabromobiphenyl, is described. The compound was found to be a potent inducer of liver microsomal drug-metabolizing enzymes in the rat, enhancing those enzymic activities induced by both phenobarbitone and 3-methylcholanthrene (i.e. cytochromes P-450 and P-448). The pentabromobiphenyl enhanced the activities of benzo[a]pyrene hydroxylase, dimethylamino-antipyrine N-demethylase and NADPH-cytochrome c reductase. The hepatic cytochromes b5 and P-450 were increased and the Soret peak maximum of the latter was shifted to 448.5 nm. The relative peak intensities and spectral shifts for the ethylisocyanide-binding difference spectra confirmed the mixed induction characteristics of 2,3',4,4',5-pentabromobiphenyl.en_US
dc.format.extent452942 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInduction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMasteren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumSchool of Public Health, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherGuelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, Unviersity of Guelph, Guelph, Ontario N1G 2W1, Canadaen_US
dc.contributor.affiliationotherGuelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, Unviersity of Guelph, Guelph, Ontario N1G 2W1, Canadaen_US
dc.identifier.pmid6243934en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23338/1/0000278.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(80)91536-3en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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