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Sensitive gas chromatographic assay for the quantitation of bretylium in plasma, urine and myocardial tissue
dc.contributor.authorPatterson, Eugeneen_US
dc.contributor.authorStetson, Philip L.en_US
dc.contributor.authorLucchesi, Benedict Roberten_US
dc.date.accessioned2006-04-07T17:27:47Z
dc.date.available2006-04-07T17:27:47Z
dc.date.issued1980-01-11en_US
dc.identifier.citationPatterson, Eugene, Stetson, Philip, Lucchesi, Benedict P. (1980/01/11)."Sensitive gas chromatographic assay for the quantitation of bretylium in plasma, urine and myocardial tissue." Journal of Chromatography B: Biomedical Sciences and Applications 181(1): 33-39. <http://hdl.handle.net/2027.42/23341>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TG9-44BNMTP-F5/2/63327b401ebf152e9bd28dd8303da7e4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23341
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7364913&dopt=citationen_US
dc.description.abstractA sensitive analytical method has been developed for the quantitation of bretylium in plasma, urine and myocardial tissue. Bretylium and the internal standard, UM-360 (o-iodobenzyltrimethylammonium), are extracted and isolated as the iodide salts. Sodium benzenethiolate is added and the mixture heated to 100[deg] for one hour. This results in the formation of 2-bromobenzyl phenyl thioether and 2-iodobenzyl phenyl thioether, which can be separated and quantitated by gas chromatography. Good reliability and reproducibility can be obtained using electron-capture detection with quantities of bretylium as small as 1 ng.en_US
dc.format.extent553182 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSensitive gas chromatographic assay for the quantitation of bretylium in plasma, urine and myocardial tissueen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology and The Upjohn Center for Clinical Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich. 48109 U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology and The Upjohn Center for Clinical Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich. 48109 U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology and The Upjohn Center for Clinical Pharmacology, The University of Michigan Medical School, Ann Arbor, Mich. 48109 U.S.A.en_US
dc.identifier.pmid7364913en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23341/1/0000282.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0378-4347(00)81266-9en_US
dc.identifier.sourceJournal of Chromatography B: Biomedical Sciences and Applicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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