Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations
dc.contributor.author | Walker, J. Michael | en_US |
dc.contributor.author | Katz, Richard J. | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.date.accessioned | 2006-04-07T17:29:47Z | |
dc.date.available | 2006-04-07T17:29:47Z | |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Walker, J. Michael, Katz, Richard J., Akil, Huda (1980)."Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations." Peptides 1(4): 341-345. <http://hdl.handle.net/2027.42/23405> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0M-47STW9M-5R/2/ae4f4011f1e538fc5243a06bb2b9c240 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23405 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7301637&dopt=citation | en_US |
dc.description.abstract | Dynorphin is a recently identified, pharmacologically potent endogenous opioid peptide. Heretofore it has not been characterized for its behavioral effects. The effects of centrally infused dynorphin upon a variety of behaviors were therefore examined in mice and rats. The present findings point to a specific profile of behavioral activity. The peptide was active in facilitating feeding and grooming, but was inactive in modifying pain sensitivity and rearing behavior. Naloxone was generally ineffective in reversing behavioral effects. Dynorphin thus appears to have some opiate-like effects upon exogenous administration but may be rapidly broken down into a behaviorally potent non-opiate peptide fragment. | en_US |
dc.format.extent | 370417 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 7301637 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23405/1/0000350.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0196-9781(80)90012-1 | en_US |
dc.identifier.source | Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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