The retina as a biochemical model of central nervous system regeneration
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.contributor.author | Feldman, Eva L. | en_US |
dc.contributor.author | Heacock, Anne M. | en_US |
dc.contributor.author | Schwartz, Michal | en_US |
dc.date.accessioned | 2006-04-07T17:30:05Z | |
dc.date.available | 2006-04-07T17:30:05Z | |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Agranoff, B. W., Feldman, E. L., Heacock, A. M., Schwartz, M. (1980)."The retina as a biochemical model of central nervous system regeneration." Neurochemistry International 1(): 487-500. <http://hdl.handle.net/2027.42/23415> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0B-485Y7PB-87/2/d804e346421298e7749522a53ace5144 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23415 | |
dc.description.abstract | The visual system of primitive vertebrates has long served as a useful model for the resynthesis of damaged neurons. The prior optic nerve crush imparts a marked tendency on the part of cultured retinal explants to extend neurites. Neurites grown in culture from retinal ganglion cells of the explant have been characterized by lectin-binding and immunohistochemical techniques. Biochemical studies on the retina following optic nerve crush reveal altered RNA and protein metabolism. Results indicate that tubulin mRNA is activated and that new tubulin synthesis is enhanced following the crush. An early and dramatic increase in the rate of nucleotide phosphokinase activity is also seen. The retinal tissue culture data, together with studies in normal and newly regrown nerve give additional insight into the nature of the regenerative process. | en_US |
dc.format.extent | 892000 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The retina as a biochemical model of central nervous system regeneration | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory, University of Michigan Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory, University of Michigan Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory, University of Michigan Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory, University of Michigan Ann Arbor, Michigan 48109, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23415/1/0000363.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0197-0186(80)90082-0 | en_US |
dc.identifier.source | Neurochemistry International | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.