Neonatal administration of [beta]-endorphin produces "chronic" insensitivity to thermal stimuli
dc.contributor.author | Sandman, Curt A. | en_US |
dc.contributor.author | McGivern, Robert F. | en_US |
dc.contributor.author | Berka, Chris | en_US |
dc.contributor.author | Michael Walker, J. | en_US |
dc.contributor.author | Coy, David H. | en_US |
dc.contributor.author | Kastin, Abba J. | en_US |
dc.date.accessioned | 2006-04-07T17:31:25Z | |
dc.date.available | 2006-04-07T17:31:25Z | |
dc.date.issued | 1979-11-12 | en_US |
dc.identifier.citation | Sandman, Curt A., McGivern, Robert F., Berka, Chris, Michael Walker, J., Coy, David H., Kastin, Abba J. (1979/11/12)."Neonatal administration of [beta]-endorphin produces "chronic" insensitivity to thermal stimuli." Life Sciences 25(20): 1755-1760. <http://hdl.handle.net/2027.42/23454> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-475WMS9-285/2/d39a9d0d3ea6731b3e555d49c60a46bf | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23454 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=575184&dopt=citation | en_US |
dc.description.abstract | Male and female rat pups were injected with [beta]-endorphin, naloxone or a saline control solution during days 2-7 postnatally. At 90 days of age the rats were tested for analgesia with the tail flick test. Testing was conducted during the first 2 hours of the light and the dark cycle. In both sexes and during both phases of the light cycle rats treated with [beta]-endorphin as infants evidenced a significant elevation in threshold for painful thermal stimuli. Early treatment with naloxone also resulted in elevated threshold for thermal stimuli. Administration of naloxone to these rats as adults did not reverse the analgesic effect. It was concluded that early exposure to [beta]-endorphin results in permanent changes in behavior perhaps by altering the interaction of endogenous opiates with their binding sites during a ciritcal period of opiate receptor development. | en_US |
dc.format.extent | 296947 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Neonatal administration of [beta]-endorphin produces "chronic" insensitivity to thermal stimuli | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Human Behavior, University of California Medical Center, Irvine and Fairview Hospital, Costa Mesa, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Human Behavior, University of California Medical Center, Irvine and Fairview Hospital, Costa Mesa, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Human Behavior, University of California Medical Center, Irvine and Fairview Hospital, Costa Mesa, USA | en_US |
dc.contributor.affiliationother | Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70140, USA | en_US |
dc.contributor.affiliationother | Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70140, USA | en_US |
dc.identifier.pmid | 575184 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23454/1/0000405.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(79)90479-X | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.