Modulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin
dc.contributor.author | Rao, K. Murali Krishna | en_US |
dc.contributor.author | Schwartz, Stanley A. | en_US |
dc.contributor.author | Good, Robert A. | en_US |
dc.date.accessioned | 2006-04-07T17:31:31Z | |
dc.date.available | 2006-04-07T17:31:31Z | |
dc.date.issued | 1979-11 | en_US |
dc.identifier.citation | Rao, K. Murali Krishna, Schwartz, Stanley A., Good, Robert A. (1979/11)."Modulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin." Cellular Immunology 48(1): 155-165. <http://hdl.handle.net/2027.42/23457> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCF-4DPM18N-1P/2/7c2cf3aa3f0e27b4753fa0f6612722fb | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23457 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=509534&dopt=citation | en_US |
dc.description.abstract | The effect of indomethacin (IND) on the mitogenic responses of human peripheral blood lymphocytes was dependent upon the dose of mitogen employed; in contrast, the effect of prostaglandins (PGs) was independent of the mitogen dose. When a single concentration of mitogen was used to study the effect of IND on blastogenesis, extremely variable results were observed, even among a healthy population group. This variability within the group was reduced to a minimum when mitogen dose-response studies were performed with and without IND and maximal blastogenic responses were compared. Employing such acriterion, no age-related differences were noted on addition of IND. Kinetic experiments revealed that significant quantities of PGs must be present very early during the culture period to influence the lectin-induced mitogenesis. These findings, together with recently published data from other laboratories, lead us to conclude that endogenously synthesized PGs may not be able to influence the lectin-induced mitogenic process. The effect of IND observed at submitogenic doses of lectins may be due to other pharmacological actions such as its effect on cyclic AMP-dependent protein kinases. | en_US |
dc.format.extent | 730803 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Modulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Memorial Sloan-Kettering Cancer Center, New York, New York 10021, U.S.A.; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Memorial Sloan-Kettering Cancer Center, New York, New York 10021, U.S.A.; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Memorial Sloan-Kettering Cancer Center, New York, New York 10021, U.S.A.; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, U.S.A. | en_US |
dc.identifier.pmid | 509534 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23457/1/0000409.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0008-8749(79)90108-4 | en_US |
dc.identifier.source | Cellular Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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