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Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid
dc.contributor.authorCulp, Brenda R.en_US
dc.contributor.authorTitus, Bradley G.en_US
dc.contributor.authorLands, William E. M.en_US
dc.date.accessioned2006-04-07T17:31:36Z
dc.date.available2006-04-07T17:31:36Z
dc.date.issued1979-11en_US
dc.identifier.citationCulp, Brenda R., Titus, Bradley G., Lands, William E. M. (1979/11)."Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid." Prostaglandines and Medicine 3(5): 269-278. <http://hdl.handle.net/2027.42/23460>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B7GHB-4C3C8RN-64/2/a9decc4cac722f28312eff42e40f1f26en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23460
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=121610&dopt=citationen_US
dc.description.abstractEicosapentaenoic acid [20:5(n-3)] is not oxidized by the purified cyclooxygenase from sheep vesicular glands in the conditions of low peroxide tone in which arachidonate [20:4(n-6)] is rapidly oxygenated. When the level of peroxide in incubation mixtures is allowed to rise, there is a dramatic change in reactivity of the cyclooxygenase to react with 20:5(n-3) at one-half the rate and one-third the extent observed with 20:4(n-6). Overall, the low peroxide levels expected in vivo would most probably cause the (n-3) type of fatty acid to be a general inhibitor of prostaglandin formation, through both reversible and irreversible actions at the enzyme site.en_US
dc.format.extent655133 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleInhibition of prostaglandin biosynthesis by eicosapentaenoic aciden_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Internal Medicine (Cardiology Division) and Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartments of Internal Medicine (Cardiology Division) and Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartments of Internal Medicine (Cardiology Division) and Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid121610en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23460/1/0000412.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0161-4630(79)90068-5en_US
dc.identifier.sourceProstaglandines and Medicineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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