Unlinked control of multiple glucocorticoid-induced processes in HTC cells
dc.contributor.author | Thompson, E. Brad | en_US |
dc.contributor.author | Granner, Darryl K. | en_US |
dc.contributor.author | Gelehrter, Thomas D. | en_US |
dc.contributor.author | Erickson, Jeanne | en_US |
dc.contributor.author | Hager, Gordon L. | en_US |
dc.date.accessioned | 2006-04-07T17:32:48Z | |
dc.date.available | 2006-04-07T17:32:48Z | |
dc.date.issued | 1979-09 | en_US |
dc.identifier.citation | Thompson, E. Brad, Granner, Darryl K., Gelehrter, Thomas, Erickson, Jeanne, Hager, Gordon L. (1979/09)."Unlinked control of multiple glucocorticoid-induced processes in HTC cells." Molecular and Cellular Endocrinology 15(3): 135-150. <http://hdl.handle.net/2027.42/23499> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T3G-47S5RC9-2H/2/e319161132d04c7ff4158d98b011783f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23499 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=39858&dopt=citation | en_US |
dc.description.abstract | HTC cell variants chosen for their lack of tyrosine aminotransferase (EC 2.6.1.5) (TAT) induction by glucocorticoids were tested for interrelated effects on other glucocorticoid responses: TAT induction by dibutyryl cyclic AMP (dBcAMP) +/- dexamethasone, glutamine synthetase (GS) induction, cyclic nucleotide phosphodiesterase (PDE) suppression, inhibition of [alpha]-aminoisobutyric acid (AIB) uptake, inhibition of plasminogen activator (PA), and induction of mouse mammary tumor virus (MTV). Loss of TAT induction by steroid was accompanied by loss of TAT induction by dBcAMP and of PDE suppression by steroid. In addition, subclones of MTV-infected cells were examined for the effect of the virus on glutamine synthetase (GS) and TAT induction. The virus had no effect on their induction in wild-type cells and no effect on GS induction in the variants. One MTV-infected subclone from a TAT variant, however, showed significant return of TAT induction. | en_US |
dc.format.extent | 1124530 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Unlinked control of multiple glucocorticoid-induced processes in HTC cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine and Human Genetics, University of Michigan Medical School, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Internal Medicine and Human Genetics, University of Michigan Medical School, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Biochemistry, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20205, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Medicine and Biochemistry, University of Iowa College of Medicine and Veterans Administration Hospital, Iowa City, IO 52242, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Tumor Virus Genetics, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20014, U.S.A. | en_US |
dc.identifier.pmid | 39858 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23499/1/0000453.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0303-7207(79)90034-0 | en_US |
dc.identifier.source | Molecular and Cellular Endocrinology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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