Dissociation of cyclic AMP accumulation from that of luteinizing hormone (LH) release in response to gonadotropin releasing hormone (GnRH) and cholera enterotoxin
dc.contributor.author | Sen, K. K. | en_US |
dc.contributor.author | Menon, K. M. J. | en_US |
dc.date.accessioned | 2006-04-07T17:36:16Z | |
dc.date.available | 2006-04-07T17:36:16Z | |
dc.date.issued | 1979-03-15 | en_US |
dc.identifier.citation | Sen, K. K., Menon, K. M. J. (1979/03/15)."Dissociation of cyclic AMP accumulation from that of luteinizing hormone (LH) release in response to gonadotropin releasing hormone (GnRH) and cholera enterotoxin." Biochemical and Biophysical Research Communications 87(1): 221-228. <http://hdl.handle.net/2027.42/23608> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-4DN979C-1DF/2/43ffbef616dc3c0a062060de1fc3a1c7 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23608 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=222268&dopt=citation | en_US |
dc.description.abstract | Anterior hemipituitaries from female rats were incubated in Krebs Ringer bicarbonate buffer, pH 7.2 containing 2 mg/ml of glucose in the absence and in the presence of GnRH or cholera enterotoxin. Following this incubation, the pituitaries were separated from the medium and cAMP and LH were assayed in the tissue and the medium, respectively. Incubations with GnRH in the range of 25 ng/ml to 400 ng/ml resulted in increase in LH release into the medium. Cholera enterotoxin at a concentration of 1 [mu]g/ml, by contrast, caused no release of LH into the medium, but caused a 5-fold increase in cAMP level and this effect was concentration dependent. Cholera enterotoxin did not interfere with the GnRH-mediated LH release. It is concluded from these experiments that the ability of GnRH to increase cAMP level may be independent of its ability to release LH. | en_US |
dc.format.extent | 497266 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Dissociation of cyclic AMP accumulation from that of luteinizing hormone (LH) release in response to gonadotropin releasing hormone (GnRH) and cholera enterotoxin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Endocrine Laboratory Department of Obstetrics and Gynecology The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Endocrine Laboratory Department of Obstetrics and Gynecology The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biological Chemistry The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 222268 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23608/1/0000570.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-291X(79)91669-3 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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