Diethanolamine-induced alteration of hepatic mitochondrial function and structure
dc.contributor.author | Barbee, S. J. | en_US |
dc.contributor.author | Hartung, Rolf | en_US |
dc.date.accessioned | 2006-04-07T17:36:20Z | |
dc.date.available | 2006-04-07T17:36:20Z | |
dc.date.issued | 1979-03-15 | en_US |
dc.identifier.citation | Barbee, S. J., Hartung, R. (1979/03/15)."Diethanolamine-induced alteration of hepatic mitochondrial function and structure." Toxicology and Applied Pharmacology 47(3): 431-440. <http://hdl.handle.net/2027.42/23610> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXH-4DDXSTT-6C/2/148edc28c6834562e158270c4339ac8f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23610 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=442087&dopt=citation | en_US |
dc.description.abstract | Diethanolamine (DEA) has been shown to interfere with phospholipid metabolism. It was hypothesized that DEA may alter membrane-bound biochemical processes which are dependent upon phospholipids. DEA was investigated for its effect on hepatic mitochondrial function and structure in the male Sprague-Dawley rat. DEA did not produce mitochondrial alterations in in vitro preparations from liver tissue. Similarly, acute treatment in vivo was without effect. However, a loss of mitochondrial integrity developed after subacute administration of DEA. Rats were given 0.25 (42 mg/kg/day), 1.0 (160 mg/kg/day), or 3.0 (490 mg/kg/day) mg/ml in their drinking water for varying periods up to 5 weeks. The effects on mitochondria were dose- and time dependent. Significant alterations appeared after 3 days at 3.0 mg/ml and after 1 week at 1.0 mg/ml. Mitochondrial State 4 activity was significantly elevated at all three dose levels following 2 weeks of DEA treatment. Concomitantly, an increase was noted in the Mg2+-dependent ATPase activity from rats treated with DEA at 2.0 mg/ml for 3 weeks. Electron micrographs indicated that treated animals had swollen hepatic mitochondria. The changes in the organelle may be related to alteration of phospholipid metabolism by DEA. | en_US |
dc.format.extent | 6086589 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Diethanolamine-induced alteration of hepatic mitochondrial function and structure | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 442087 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23610/1/0000572.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0041-008X(79)90512-X | en_US |
dc.identifier.source | Toxicology and Applied Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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