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Oxidative metabolism of xenobiotics during pregnancy: Significance of microsomal flavin-containing monooxygenase

dc.contributor.authorOsimitz, T. G.en_US
dc.contributor.authorKulkarni, Arun P.en_US
dc.date.accessioned2006-04-07T17:44:59Z
dc.date.available2006-04-07T17:44:59Z
dc.date.issued1982-12-31en_US
dc.identifier.citationOsimitz, T. G., Kulkarni, A. P. (1982/12/31)."Oxidative metabolism of xenobiotics during pregnancy: Significance of microsomal flavin-containing monooxygenase." Biochemical and Biophysical Research Communications 109(4): 1164-1171. <http://hdl.handle.net/2027.42/23765>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DYN48C-275/2/369e280bab5150fe076c4caaa6ee6d8een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23765
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7168761&dopt=citationen_US
dc.description.abstractPregnancy related changes in oxidative metabolism of model substrates were examined in CD1 mice. As compared to nonpregnant females, a significant decrease in the hepatic microsomal aminopyrine-but not in dimethylaniline-N-demethylase activity was observed in pregnant mice. The rates of microsomal flavin-containing monooxygenase-catalyzed N-oxidation of dimethylaniline remained relatively unchanged during pregnancy in the liver, lung, kidney, and uterus. In contrast to this, N-oxidase activity of placental microsomes was increased nearly 5-fold when measured at day 12 and 18 of gestation.en_US
dc.format.extent454885 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleOxidative metabolism of xenobiotics during pregnancy: Significance of microsomal flavin-containing monooxygenaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumToxicology Research Laboratory, Department of Environmental and Industrial Health, School of Public Health The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumToxicology Research Laboratory, Department of Environmental and Industrial Health, School of Public Health The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid7168761en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23765/1/0000001.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(82)91899-Xen_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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