Compounds of novel structure having kappa-agonist behavioral effects in Rhesus monkeys
dc.contributor.author | Katz, Jonathan L. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Winger, Gail D. | en_US |
dc.contributor.author | Jacobson, Arthur E. | en_US |
dc.date.accessioned | 2006-04-07T17:46:22Z | |
dc.date.available | 2006-04-07T17:46:22Z | |
dc.date.issued | 2006-04-07T17:46:22Z | |
dc.identifier.citation | Katz, Jonathan L., Woods, James H., Winger, Gail D., Jacobson, Arthur E. ()."Compounds of novel structure having kappa-agonist behavioral effects in Rhesus monkeys." Life Sciences 31(20-21): 2375-2378. <http://hdl.handle.net/2027.42/23805> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-47CJ8BC-5G/2/d249d6db7e17e8a1bfae67b55b28cac8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23805 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6298529&dopt=citation | en_US |
dc.description.abstract | The kappa-agonist behavioral effects of several compounds were studied in rhesus monkeys and mice. Rhesus monkeys trained to discriminate ethylketazocine from saline responded as if ethylketazocine had been administered when given bridged oripavines with either N-allyl or N-cyclopropylmethyl, but not N-methyl, substituents. These compounds had C7 substitutions of either 2-hydroxy-2-pentyl or 2-hydroxy-5-methyl-2-hexyl. Monkeys also showed ethylketazocine-like responding when given U-50, 488 (-3,4-dichloro-N-methyl-N-[2- (1-pyrrolidinyl) cyclohexyl]- benzeneacetamide), a compound with an atypical structure not resembling any known narcotic. Additionally, ethylketazocine-like responding was produced by two 5,9-alpha dimethyl 6-7-benzomorphans with either an N-2-methoxyisobutyl or an N-2-methoxypropyl substituent. The latter compound was the only compound active in producing ethylketazocine-like discriminative effects that also reversed morphine-withdrawal signs. The N-methyl bridged oripavines that were inactive in producing ethylketazocine-like discriminative effects reversed morphine withdrawal signs. | en_US |
dc.format.extent | 255942 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Compounds of novel structure having kappa-agonist behavioral effects in Rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Medicinal Chemistry Section, Laboratory of Chemistry National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, MD, USA | en_US |
dc.identifier.pmid | 6298529 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23805/1/0000043.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(82)90160-6 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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