Vascular reactivity and high dietary eicopentaenoic acid
dc.contributor.author | Lockette, Warren E. | en_US |
dc.contributor.author | Webb, R. Clinton | en_US |
dc.contributor.author | Culp, Brenda R. | en_US |
dc.contributor.author | Pitt, Bertram | en_US |
dc.date.accessioned | 2006-04-07T17:46:55Z | |
dc.date.available | 2006-04-07T17:46:55Z | |
dc.date.issued | 1982-11 | en_US |
dc.identifier.citation | Lockette, Warren E., Webb, R. Clinton, Culp, Brenda R., Pitt, Bertram (1982/11)."Vascular reactivity and high dietary eicopentaenoic acid." Prostaglandins 24(5): 631-639. <http://hdl.handle.net/2027.42/23822> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T3H-47N6W0N-Y0/2/89ea511ae17f56ffa053f9774e56551a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23822 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6298902&dopt=citation | en_US |
dc.description.abstract | Epidemiologic studies suggest that high dietary intake of eicosapentaenoic acid (EPA), a precursor of the trienoic prostaglandins, is associated with a low incidence and reduced extent of myocardial infarction. Vascular reactivity of isolated aortic strips from rats maintained for 3 weeks on a control diet or on a diet supplemented with menhaden fish oil (17% EPA) was examined with norepinephrine, sodium arachidonate, KCl, PGF2[alpha] and nitroprusside. Aortic strips from rats fed the fish oil diet were significantly less responsive to the contractile effects of norepinephrine and arachidonate compared to those from control diet rats. Treatment of aortic strips with indomethacin decreased responsiveness to norepinephrine. The magnitude of the decrease was greater in control rats resulting in a similar vascular response between the 2 groups after blockade. Contractions to arachidonate were abolished by indomethacin. There were no differences in vascular responses to KCl, PGF2[alpha] and nitroprusside in aortic strips from control diet rats and those from the fish oil diet rats. Aortic strips from the fish oil diet rats contained more EPA than those from the control diet rats. Thus, the contractile effect of norepinephrine in isolated rat aortic strips is normally augmented by intrinsic prostaglandins, and this augmentation is diminished by dietary intake of EPA. | en_US |
dc.format.extent | 406073 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Vascular reactivity and high dietary eicopentaenoic acid | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 6298902 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23822/1/0000061.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-6980(82)90033-8 | en_US |
dc.identifier.source | Prostaglandins | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.