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Dynorphin immunocytochemistry in the rat central nervous system

dc.contributor.authorKhachaturian, Henryen_US
dc.contributor.authorWatson, Stanley J.en_US
dc.contributor.authorLewis, Michael E.en_US
dc.contributor.authorCoy, David H.en_US
dc.contributor.authorGoldstein, Avramen_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2006-04-07T17:46:57Z
dc.date.available2006-04-07T17:46:57Z
dc.date.issued1982en_US
dc.identifier.citationKhachaturian, Henry, Watson, Stanley J., Lewis, Michael E., Coy, David, Goldstein, Avram, Akil, Huda (1982)."Dynorphin immunocytochemistry in the rat central nervous system." Peptides 3(6): 941-954. <http://hdl.handle.net/2027.42/23823>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0M-47STXM9-TX/2/528aee2d5ae781097b9dd7eabdf7387fen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23823
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6132365&dopt=citationen_US
dc.description.abstractThe distribution of dynorphin in the central nervous system was investigated in rats pretreated with relatively high doses (300-400 [mu]g) of colchicine administered intracerebroventricularly. To circumvent the problems of antibody cross-reactivity, antisera were generated against different portions as well as the full dynorphin molecule (i.e., residues 1-13, 7-17, or 1-17). For comparison, antisera to [Leu]enkephalin (residues 1-5) were also utilized. Dynorphin was found to be widely distributed throughout the neuraxis. Immunoreactive neuronal perikarya exist in hypothalamic magnocellular nuclei, periaqueductal gray, scattered reticular formation sites, and other brain stem nuclei, as well as in spinal cord. Additionally, dynorphin-positive fibers or terminals occur in the cerebral cortex, olfactory bulb, nucleus accumbens, caudate-putamen, globus pallidus, hypothalamus, substantia nigra, periaqueductal gray, many brain stem sties, and the spinal cord. In many areas studied, dynorphin and enkephalin appeared to form parallel but probably separate anatomical systems. The results suggest that dynorphin occurs in neuronal systems that are immunocytochemically distinct from those containing other opioid peptides.en_US
dc.format.extent1709384 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDynorphin immunocytochemistry in the rat central nervous systemen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70195, USAen_US
dc.contributor.affiliationotherAddiction Research Foundation, Stanford University, Palo Alto, CA 94394, USAen_US
dc.identifier.pmid6132365en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23823/1/0000062.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0196-9781(82)90063-8en_US
dc.identifier.sourcePeptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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