Effects of -[alpha]-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis
dc.contributor.author | Bledsoe, Sanford C., Jr. | en_US |
dc.contributor.author | Bobbin, Richard P. | en_US |
dc.date.accessioned | 2006-04-07T17:47:07Z | |
dc.date.available | 2006-04-07T17:47:07Z | |
dc.date.issued | 1982-10-23 | en_US |
dc.identifier.citation | Bledsoe, Jr., Sanford C., Bobbin, Richard P. (1982/10/23)."Effects of -[alpha]-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis." Neuroscience Letters 32(3): 315-320. <http://hdl.handle.net/2027.42/23828> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485H5RV-D4/2/5aa0df41aed6c62d3a0b7db3d6da6770 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23828 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6129604&dopt=citation | en_US |
dc.description.abstract | The effects of -[alpha]-aminoadipate (D[alpha]AA) on excitation of afferent nerve fibers in the Xenopus laevis lateral line were studied in vitro. D[alpha]AA reversibly suppressed spontaneous activity and excitation induced by water motion at concentrations as low as 0.25-0.5 mM. Higher concentrations (up to 10 mM) caused a greater suppression that was rapidly and fully reversible. -[alpha]-Aminoadipate at 0.25-1.0 mM had no suppressive effects. Responses elicited by NMDA (1.0-2.0 mM) were the most sensitive to D[alpha]AA (0.25-0.5 mM), those elicited by -aspartate and -glutamate (1.0-2.0 mM) were less sensitive and similar, and those elicited by kainate (5-15 [mu]M) were the least sensitive. The results provide evidence that the transmitter released by hair cells in the Xenopus lateral line interacts postsynaptically with NMDA-preferring receptors and that the transmitter is an excitatory amino acid, possibly -glutamate of -aspartate. | en_US |
dc.format.extent | 1465405 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of -[alpha]-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Louisiana State University Medical School, Department of Otorhinolaryngology and Biocommunication, Kresge Hearing Research Laboratory of the South, New Orleans, LA 70119, U.S.A.; Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Louisiana State University Medical School, Department of Otorhinolaryngology and Biocommunication, Kresge Hearing Research Laboratory of the South, New Orleans, LA 70119, U.S.A. | en_US |
dc.identifier.pmid | 6129604 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23828/1/0000067.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(82)90313-5 | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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