Receptor-related interactions of opiates with PGE-induced adneylate cyclase in brain
dc.contributor.author | Barchfeld, Cynthia C. | en_US |
dc.contributor.author | Maassen, Zaiga F. | en_US |
dc.contributor.author | Medzihradsky, Fedor | en_US |
dc.date.accessioned | 2006-04-07T17:47:16Z | |
dc.date.available | 2006-04-07T17:47:16Z | |
dc.date.issued | 2006-04-07T17:47:16Z | |
dc.identifier.citation | Barchfeld, Cynthia C., Maassen, Zaiga F., Medzihradsky, Fedor ()."Receptor-related interactions of opiates with PGE-induced adneylate cyclase in brain." Life Sciences 31(16-17): 1661-1665. <http://hdl.handle.net/2027.42/23833> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-478B4R6-22T/2/9bc292ca1f3f93e76e61d2333fb4eaf2 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23833 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6296567&dopt=citation | en_US |
dc.description.abstract | The inhibition by opiates of the PGE2-induced formation of cAMP in slices from rat brain striatum was investigated. A maximal, 3.5-fold increase over the basal level of cAMP was obtained with an EC50 for PGE2 of 3 [mu]M. Opiate agonists of both [mu] and [kappa] type were inhibitory. The IC50 values for morphine, levorphanol and ethylketocyclazocine (EKC) were 110 nM, 80 nM and 25 nM, respectively. These values were similar to the potencies of the compounds in displacing steroespecifically bound 3H-etorphine in rat brain membranes. As evidenced by the inactivity of dextrorphan, the inhibition of PGE2-dependent cAMP formation was stereospecific. Also ineffective were the opiate antagonists naloxone, naltrexone and Mr 2266. These compounds did, however, reverse the inhibition by agonists, displaying thereby selectivity toward the putative [mu] and [kappa] opiates. Thus, the inhibition by morphine was antagonized to a greater degree by naloxone than by MR 2266, and the action of EKC was blocked more effectively by MR 2266 relative to naloxone. | en_US |
dc.format.extent | 260000 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Receptor-related interactions of opiates with PGE-induced adneylate cyclase in brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Departments of Biological Chemistry and Pharmacology The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 6296567 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23833/1/0000072.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(82)90180-1 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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