Griffonia simplicifolia I lectin mediates macrophage-induced cytotoxicity against Ehrlich ascites tumor
dc.contributor.author | Maddox, Daniel E. | en_US |
dc.contributor.author | Goldstein, Irwin J. | en_US |
dc.contributor.author | LoBuglio, Albert F. | en_US |
dc.date.accessioned | 2006-04-07T17:50:12Z | |
dc.date.available | 2006-04-07T17:50:12Z | |
dc.date.issued | 1982-07-15 | en_US |
dc.identifier.citation | Maddox, Daniel E., Goldstein, Irwin J., Lobuglio, Albert F. (1982/07/15)."Griffonia simplicifolia I lectin mediates macrophage-induced cytotoxicity against Ehrlich ascites tumor." Cellular Immunology 71(1): 202-207. <http://hdl.handle.net/2027.42/23924> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCF-4DKVBF7-7W/2/fc11fd8eae9a68ad667a3cfba6c0c63a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23924 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7139719&dopt=citation | en_US |
dc.description.abstract | The concurrent administration of Griffonia simplicifolia lectin into the peritoneal cavity of mice has been reported to protect them from challenge with Ehrlich ascites tumor cells. This study demonstrates that the GS I lectin is capable of binding to the surface of both inflammatory macrophages and Ehrlich ascites tumor cells and can mediate macrophage lectin-dependent cytotoxicity to this tumor cell line. The lectin was not found to be toxic to Ehrlich ascites tumor cells directly or to nonspecifically initiate complement-mediated lysis of these target cells. The macrophage lectin-dependent cytotoxicity could be specifically inhibited by the haptenic sugar methyl [alpha]--galactopyranoside. Thus, this lectin appears to be able to provide a linkage between effector macrophages and Ehrlich ascites tumor cells resulting in the triggering of a cytolytic event. | en_US |
dc.format.extent | 701111 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Griffonia simplicifolia I lectin mediates macrophage-induced cytotoxicity against Ehrlich ascites tumor | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Section of Allergy and Clinical Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Section of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 7139719 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23924/1/0000169.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0008-8749(82)90509-3 | en_US |
dc.identifier.source | Cellular Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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