Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate
dc.contributor.author | Johnston, Michael V. | en_US |
dc.contributor.author | Haddad, R. | en_US |
dc.contributor.author | Carman-Young, A. | en_US |
dc.contributor.author | Coyle, J. T. | en_US |
dc.date.accessioned | 2006-04-07T17:50:38Z | |
dc.date.available | 2006-04-07T17:50:38Z | |
dc.date.issued | 1982-07 | en_US |
dc.identifier.citation | Johnston, M. V., Haddad, R., Carman-Young, A., Coyle, J. T. (1982/07)."Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate." Developmental Brain Research 4(3): 285-291. <http://hdl.handle.net/2027.42/23938> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYW-483SMNT-4/2/8bd9fb715d356ea0185447ea31409dc0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23938 | |
dc.description.abstract | Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, [gamma]-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat. | en_US |
dc.format.extent | 863743 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Neuroteratology Laboratory, New York State Institute for Basic Research in Mental Retardation, Staten Island, NY 10314, U.S.A. | en_US |
dc.contributor.affiliationother | Departments of Neuroscience, Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, U.S.A. | en_US |
dc.contributor.affiliationother | Departments of Neuroscience, Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, U.S.A. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23938/1/0000185.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-3806(82)90140-7 | en_US |
dc.identifier.source | Developmental Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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