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The effect of gentamicin on calcium uptake by renal mitochondria
dc.contributor.authorSastrasinh, Malineeen_US
dc.contributor.authorWeinberg, Joel M.en_US
dc.contributor.authorDavid Humes, H.en_US
dc.date.accessioned2006-04-07T17:50:56Z
dc.date.available2006-04-07T17:50:56Z
dc.date.issued1982-06-28en_US
dc.identifier.citationSastrasinh, Malinee, Weinberg, Joel M., David Humes, H. (1982/06/28)."The effect of gentamicin on calcium uptake by renal mitochondria." Life Sciences 30(26): 2309-2315. <http://hdl.handle.net/2027.42/23947>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-478B2KD-1FX/2/62301282b6b93f69d3b2fc65282c404fen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/23947
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6810049&dopt=citationen_US
dc.description.abstractThe effect of the nephrotoxic aminoglycoside antibiotic, gentamicin, on calcium uptake by renal cortical mitochondria was assessed in vitro. Gentamicin was found to be a competitive inhibitor of mitochondrial Ca++ uptake. This effect displayed a dose response with a Ki of 233 [mu]M and occurred at gentamicin concentrations below those that inhibit mitochondrial electron transport. These results further demonstrate the potential for gentamicin to alter membrane function and thereby contribute to toxic cell injury via its interactions with divalent cations.en_US
dc.format.extent364174 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe effect of gentamicin on calcium uptake by renal mitochondriaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Internal Medicine, Veterans Administration Medical Center and University of Michigan, Ann Arbor, Michigan 48105, USAen_US
dc.contributor.affiliationumDepartments of Internal Medicine, Veterans Administration Medical Center and University of Michigan, Ann Arbor, Michigan 48105, USAen_US
dc.contributor.affiliationumDepartments of Internal Medicine, Veterans Administration Medical Center and University of Michigan, Ann Arbor, Michigan 48105, USAen_US
dc.identifier.pmid6810049en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/23947/1/0000194.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(82)90258-2en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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