Glycoprotein requirement for neurite outgrowth in goldfish retina explants: Effects of tunicamycin
dc.contributor.author | Heacock, Anne M. | en_US |
dc.date.accessioned | 2006-04-07T17:51:06Z | |
dc.date.available | 2006-04-07T17:51:06Z | |
dc.date.issued | 1982-06-10 | en_US |
dc.identifier.citation | Heacock, Anne M. (1982/06/10)."Glycoprotein requirement for neurite outgrowth in goldfish retina explants: Effects of tunicamycin." Brain Research 241(2): 307-315. <http://hdl.handle.net/2027.42/23952> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-484M9HC-1NT/2/8002fb8b8de5d903a8665eda77032937 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/23952 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6896669&dopt=citation | en_US |
dc.description.abstract | The role of glycoproteins in neurite outgrowth in vitro has been examined using the protein glycosylation inhibitor, tunicamycin. The concentration-dependent inhibitory effects of tunicamycin on neuritic outgrowth from goldfish retinal explants closely paralleled its effects on the dolichol pathway of glycoprotein biosynthesis. The neurite membrane assembled in the presence of an intermediate dose of tunicamycin (5 [mu]g/ml) was deficient in carbohydrate, as indicated by a reduced capacity to bind the lectins Concanavalin A, wheat germ agglutinin and ricin. These results suggest that tunicamycin may prove useful in assessing the role of cell surface carbohydrate in neuronal recognition phenomena. | en_US |
dc.format.extent | 996426 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Glycoprotein requirement for neurite outgrowth in goldfish retina explants: Effects of tunicamycin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 6896669 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/23952/1/0000199.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(82)91068-X | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.